MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis

Table 1

Percentages of reduction in bond strength during the follow-up period.

Article	Adhesive/mixed failure modes (%) in groups immediately/after aging	N	Technique of bonding (E&R/SE) MMP inhibitor + %	Bond strength reduction (%) after aging
				6 m	12 m	>12 m
Li et al. [9]	NA	NA	E&R
			DMSO 1%	17.4
			GD 5%	11.9
			BAI 2.5 μg/mL	10.1
			Control	36.0
Malaquias et al. [10]	Group: immediate/24 m; Ambar®	50	E&R			24 m
	CHX 0.01%: 79.2/84.3		CHX 0.01%			16.7
	CHX 0.05%: 81.3/88.1		CHX 0.05%			17.0
	CHX 0.1%: 80.5/86.9		CHX 0.1%			10.0
	CHX 0.2%: 72.7/76.8		CHX 0.2%			10.4
	Control: 81/83.4		Control			40.2
	Group: immediate/24 m; XP-Bond®		E&R
	CHX 0.01%: 75.7/77.7		CHX 0.01%			33.8
	CHX 0.05%: 81/78.4		CHX 0.05%			32.1
	CHX 0.1%: 69.8/94.8		CHX 0.1%			29.1
	CHX 0.2%: 74/82.1		CHX 0.2%			29.3
	Control: 81.6/77.2		Control			53.3
Ou et al. [11]	Group: immediate/6 m/12 m	60	E&R
	MMP8-I/90/70/75		MMP8-I	1.1	1.8
	CHX 2%: 100/95/95		CHX 2%	0.7	5.3
	Control: 95/80/90		Control	17.2	24.1
El Gezawi et al. [12]	Group: immediate/6 m; µTBS	48
	MDPB: 68/74		MDPB-SE	30.2
	BAC: 68/72		BAC-PA	58.5
	Control: 72/78		Control	64.3
	4-point loading
	MDPB: 68/70		MDPB-SE	31.6
	BAC: 72/86		BAC-PA	62.9
	Control: 78/84		Control	69.1
Maravic et al. [13]	Group: immediate/12 m	36	E&R
	ACR: 65/90		ACR 0.01%		14.4
	Control: 67/82		Control		46.1
Giacomini et al. [14]	Group: immediate/6 m; Normal dentin	90	E&R
	CHX 2%: 100/100		CHX 2%	41.8
	E-64: 96/96		E-64 5 μm	26.6
	Control: 96/92		Control	22.3
	Artificially carious dentin
	CHX 2%: 100/100		CHX 2%	9.9
	E-64: 96/96		E-64. 5 μm	15.1
	Control: 100/100		Control	13.4
	Eroded dentin
	CHX 2%: 100/100		CHX 2%	10.7
	E-64: 100/100		E-64 5 μm	8.4
	Control/96/100		Control	12.7
Daood et al. [15]	Group: immediate/12 m; Adper™ Single Bond 2	60	E&R
	CHX 2%: 64/72		CHX 2%	4	8
	QAS 2%: 52/65		QAS 2%	−8.1	−3.6
	QAS 5%: 75/64		QAS 5%	4.2	−6.0
	QAS 10%: 72/67		QAS 10%	10.5	23.1
	Control: 63/66		Control	14.5	29.5
	Prime & Bond® NT™		E&R
	CHX 2%: 80/55		CHX 2%	3.3	8.8
	QAS 2%: 59/64		QAS 2%	−2.2	−4.4
	QAS 5%: 74/74		QAS 5%	5.6	11.3
	QAS 10%: 75/79		QAS10%	6.9	13.8
	Control: 64/74		Control	12.2	20.9
Venigalla et al. [16]	Group: immediate/6 m	80	E&R
	RF WWB: 73/47		RF 0.1% WWB	2.5
	CD WWB: 73/60		1 m CD WWB	5.6
	PAC WWP: 67/47		6.5% PAC WWB	17
	Control WWB: 87/60		Control WWB	24
	RF EWB: 53/47		RF 0.1% EWB	0.6
	CD EWB: 67/60		1 m CD EWB	4.7
	PAC EWB: 60/53		6.5% PAC EWB	5.6
	Control EWB: 67/47		Control EWB	10.2
Carvalho et al. [17]	Group: immediate/6 m	30	E&R
	Green tea: 36/68		Green tea 2%	−55.2
	CHX 2%: 66/78		CHX 2%	1.3
	Control: 81/68		Control	11.1
Barcellos et al. [18]	NA	60	E&R
			ZnOn 1 wt.%	3.1
			Zn-Mt, 1 wt.%	46.1
			Control	44.4
Hass et al. [19]	NA	40	E&R Single Bond Plus®			18 m
			PAC 6.5wt%			11.9
			UVA-RF 0.1wt%			14.8
			GD 5wt%			22.9
			Control			64.8
			E&R Tetric N-Bond®
			PAC 6.5wt%			5.5
			UVA-RF 0.1wt%			20.3
			GD 5wt%			32.2
			Control			62.2
Loguercio et al. [20]	Group: immediate/24 m; Prime & Bond NT®	30	E&R			24 m
	MC 2%: 97/94		MC 2%			10.6
	CHX 2%: 85/94		CHX 2%			17.9
	Control: 80/78		Control			44.2
	Adper™ Single Bond 2		E&R
	MC 2%: 98/96		MC 2%			10.9
	CHX 2%: 93/90		CHX 2%			13.9
	Control: 93/95		Control			30.1
Hass et al. [21]	Group: immediate/6 m	10	E&R
	PAC 2%-PA: 84/82		PAC 2%-PA	−2.7
	Control: 97/100		Control	47.2
Tekçe et al. [22]	Group: immediate/12 m; SB Universal®	50
	BAC 1%: 58/75.5		BAC 1%		23
	CHX 2%: 70.4/76		CHX 2%		8.9
	EDTA 0.5 m: 66.1/73.4		EDTA 0.5 m		−0.9
	SE: 60.6/78.3		SE control		3.6
	E&R: 58.4/79		E&R control		13.1
	All-Bond Universal®
	BAC 1%: 70.2/71		BAC 1%		15.2
	CHX 2%: 60.5/73.5		CHX 2%		19.4
	EDTA 0.5 m/57/76		EDTA 0.5 m		17.6
	SE: 78.6/90		SE control		21.6
	E&R: 65.5/71		E&R control		12.0
Abu Nawareg et al. [23]	Group: immediate/6 m/12 m	36	E&R
	CHX 2%: 93.3/86.7/86.7		CHX 2%	3.5	5.9
	CHX-MA 2%: 86.7/100/80		CHX-MA 2%	−5.1	−4.9
	Control: 93.3/100/86.7		Control	22.9	33.3
da Silva et al. [24]	Group: immediate/6 m/12 m; Experimental adhesive	36	E&R
	GAL 5 μm: 77/77/59		GAL 5 μm	13.3	17.5
	BAT 5 μm:71/71/84		BAT 5 μm	10.9	15.3
	GM1 5 μm: 72/72/57		GM1 5 μm	11.5	15.1
	CHX 2%: 70/72/63		CHX 2%	12.5	13.9
	Control: 79/75/83		Control	0.1	23.5
	Single Bond 2: 68/74/84		Single Bond 2	5.7	20.3
Montagner et al. [25]	NA	36	E&R			18 m
			CHX 2%			20.6
			NaOCl			25.7
			Control			44.6
Sabatini et al. [26]	NA	25	E&R
			CHX 2%		1.3
			BAC-PA 1%		53.2
			BAC 0.5%		9.1
			BAC 1%		28.3
			Control		43.9
Sabatini and Pashley [27]	NA	35	E&R
			0.5% BAC	−2.6	1.6
			1.0% BAC	4.5	−7.0
			2.0% BAC	5.5	13.4
			0.5% MBAC	−11.2	−26.4
			1.0% MBAC	−5.4	−23.1
			2.0% MBAC	5.6	1.0
			Control	44.2	48.0
André et al. [28]	NA	60	E&R
			GD		5.8
			GD-control		32.1
			MDPB		−8.9
			MDPB-control		19.2
			0.2% CHX		2.5
			0.2% CHX-control		13.5
Manso et al. [29]	Group: immediate/6 m/15 m; All-Bond 3®	48	E&R			15 m
	CHX 1% W: 73.5/51.6/58.3		CHX 1% water	−7.9		1.9
	Control W: 50/44.5/50		Control water	−11.9		7.4
	CHX 1% E: 75/55.8/65.3		CHX 1% ethanol	4.6		27.6
	Control E: 56.8/62.7/54.1		Control ethanol	5.1		25.3
	Excite®		E&R
	CHX 1% W: 77.7/73.8/76		CHX 1% water	8.2		−2.1
	Control W: 78/81.5/69.1		Control water	15.0		8.1
	CHX 1% E: 62.1/47.2/59.2		CHX 1% ethanol	−7.7		7.2
	Control E: 56.7/41.2/76.6		Control ethanol	10.3		14.5
Ekambaram et al. [30]	Group: immediate/12 m; Sound dentin	48	E&R
	EWB + CHX: 93.7/75		EWB + CHX 2%		4.9
	EWB control: 100/68.8		EWB control		21.2
	WWB + CHX: 100/100		WWB + CHX		0.3
	WWB control: 93.8/100		WWB control		27.6
	Caries-affected dentin		E&R
	EWB + CHX: 68.8/81.2		EWB + CHX		6.4
	EWB control: 75.5/62.6		EWB control		14.4
	WWB + CHX: 50/100		WWB + CHX		18.7
	WWB control: 56.3/62.5		WWB control		60.9
Sabatini and Patel [31]	Group: immediate/6 m/18 m; OptiBond Solo Plus®	140	E&R			18 m
	2% CHX: 70/70/60		2% CHX	12.4		6.0
	BAC‐PA: 60/60/60		BAC‐PA	−4.7		−27.1
	0.25% BAC: 60/70/60		0.25% BAC	32.4		30.9
	0.5% BAC: 70/70/80		0.5% BAC	1.8		−95.0
	1.0% BAC: 70/70/100		1.0% BAC	−21.2		-46.3
	2.0% BAC: 80/70/70		2.0% BAC	15.7		−19.1
	Control: 70/70/80		Control	−3.5		−1.9
	All-Bond 3®		E&R			18 m
	2% CHX: 80/70/70		2% CHX	−13.8		15.5
	BAC‐PA: 90/80/50		BAC‐PA	−26.5		−9.6
	0.25% BAC: 70/70/60		0.25% BAC	11.1		−33.3
	0.5% BAC: 70/60/70		0.5% BAC	9.8		−41.0
	1.0% BAC: 90/80/90		1.0% BAC	−0.5		−22.2
	2.0% BAC: 90/80/70		2.0% BAC	10.7		−8.5
	Control: 80/70/70		Control	−20.9		−15
Pomacóndor-Hernández et al. [32]	NA	8	SE
			CHX 2%	−8.1
			Control	2.7
Verma et al. [33]	NA	120	E&R Solobond M®
			CHX 2%	−8.6
			PAC 30%	6.8
			Control	45.1
			Tetric N Bond®
			CHX 2%	0.9
			PAC 30%	0.7
			Control	36.2
Tjäderhane et al. [34]	NA	20	DMSO 0.5 mm	−15.7	−36.4
			Control	37.2	30.4
			DMSO 0.5 mm	−12	−6.6
			Control	22.2	42.0
Sabatini et al. [35]	Group: immediate/6 m	25	E&R
	CHX 2%: 70/60		CHX 2%	10.4
	BAC-PA: 80/80		BAC 1% PA	18.4
	BAC 0.5%: 70/80		BAC 0.5%-adhesive	−0.5
	BAC 01%: 80/70		BAC 1%-adhesive	−4.9
	Control: 70/60		Control	20.1
Simoes et al. [36]	NA	36	E&R
			CHX	28.5
			Control	32.7
			CHX + ethanol	21.4
			Ethanol control	7.6
Sabatini [37]	Group: immediate/6 m	120	E&R
	CHX 2% + 0.2% CHX-adhesive: 70/50		CHX 2% + 0.2% CHX-adhesive	−4.2
	0.2%-adhesive: 80/60		0.2% CHX-adhesive	5.2
	Control: 90/70		Control	−14.3
			SE
	CHX 2% + 0.2% CHX-adhesive: 60/60		CHX 2% + 0.2% CHX-adhesive	−13.8
	0.2% CHX-adhesive: 50/80		0.2% CHX-adhesive	−17.4
	Control: 60/80		Control	−6.3
Ali et al. [38]	NA	30	SE
			2% CHX-ethanol	64.2
			2% CHX-dH2O	−13.8
			Control	36.5
Leitune et al. [39]	NA	40	E&R
			CHX 2%	−9.8
			Control	10.9
Cova et al. [40]	Group: immediate/6 m/12 m	60	E&R
	RF 0.1%: 98/95/97		RF 0.1%	19.8	30.4
	Control: 89/89/95		Control	41.0	52.6
Mobarak [41]	NA	120	SE			24 m
			CHX 2%			ND 63.3 AD 52.1
			CHX 5%			ND 57.7 AD 28.8
			Control			ND 61.1 AD 54.1
Sadek et al. [42]	NA	42	E&R SB Multipurpose®
			CHX 2% WWB			9 m: 9.5 18 m: 26.1
			Control			9 m: 15.5 18 m: 26.2
			Single Bond 2®
			CHX 2% WWB			9 m: 10.4 18 m: 32.4
			Control			9 m: 18.9 18 m: 25.7
			Experimental
			CHX 2% EWB			9 m: 4.7 18 m: 7.0
			Control			9 m: 3.0 18 m:3.3
Stanislawczuk et al. [43]	NA	42	E&R Prime & Bond NT®			24 m
			Control			53.5
			CHX			19.2
			CHX-PA			21.8
			E&R Adper Single Bond®
			Control			46.9
			CHX			18.9
			CHX-PA			16.3
De Munck et al. [44]	Group: Immediate/6 m/12 m; Scotchbond 1XT®	45	E&R
	Control: 20/70/70		Control	42.9	49.5
	CHX: 63/69/100		CHX	41.4	78.9
	SB‐3CT: 33/100/100		SB‐3CT	76.5	93.6
	Clearfil Protect Bond®		SE
	Control: 0/60/54		Control	21	33.5
	CHX: 0/63/67		CHX	33.1	48.3
	SB-3CT: 6/32/82		SB-3CT	30.4	57.5
	G-Bond®		SE
	Control: 95/95/100		Control	52.1	66.2
	CHX: 90/93/100		CHX	35.3	79.1
	SB-3CT: 89/100/100		SB-3CT	62.3	60.8
Ricci et al. [45]	Group: immediate/10–12 m/18–20 m	26	E&R		10–12 m	18–20 m
	CHX 2%: 100/100/100		CHX 2%		26.3	37.0
	Control: 75/87.5/100		Control		43.9	56.5
Breschi et al. [46]	Group: immediate/12 m	28	E&R
	GAL/85/75		GAL 0.04%		26.5
	Control: 65/76		Control		45.4
Breschi et al. [47]	Group: immediate/24 m	48	E&R			24 m
	Control: 100/80		Control			67.2
	CHX 0.2%: 85/100		CHX 0.2%			16.8
	CHX 2%: 90/75		CHX 2%			30.8
Loguercio et al. [48]	Group: immediate/6 m; Prime & Bond 2.1®	120	E&R
	Control: 75/80.9		Control	33.4
	0.002%: 77.6/71.7		CHX 0.002%	11
	0.02%: 67.9/75		CHX 0.02%	−0.7
	0.2%: 87.5/94.1		CHX 0.2%	11.3
	2%: 75/94.4		CHX 2%	8.5
	4%: 88.2/76		CHX 4%	21
	Adper Single Bond®		E&R
	Control: 81.2/69		Control	29
	0.002%: 73.5/76.1		CHX 0.002%	11.6
	0.02%: 46.4/75		CHX 0.02%	9.6
	0.2%: 80/88		CHX 0.2%	−5.8
	2%: 84.1/97.1		CHX 2%	12.7
	4%: 77.6/70.2		CHX 4%	7.6
Stanislawczuk et al. [49]	Group: immediate/6 m; Prime & Bond NT®	42	E&R
	Control: 67/75.8		Control	33.6
	CHX 2%: 75/96.5		CHX 2%	−6.8
	CHX 2%-PA: 83/72.4		CHX 2%-PA	16
	Single Bond 2®		E&R
	Control: 85/64.3		Control	25
	CHX 2%: 96.3/100		CHX 2%	0
	CHX 2%-PA: 87.6/76.9		CHX 2%-PA	4.6
Zhou et al. [50]	Group: immediate/12 m	16	SE
	0.05% CHX: 93.8/100		0.05% CHX		18.1
	Control: 87.5/93.8		Control		18.7
	0.1% CHX: 75/93.8		0.1% CHX		−0.8
	Control: 93.8/100		Control		16.0
	0.5% CHX: 87.5/100		0.5% CHX		5.9
	Control: 93.8/100		Control		21.8
	1% CHX/93.8/93.8		1% CHX		2.9
	Control: 87.5/100		Control		15.6
Breschi et al. [51]	Group: immediate/6 m/12 m; Single Bond 1XT®	108	E&R
	CHX 2%: 90/95/95		CHX 2%	11	24.6
	CHX 0.2%: 100/95/100		CHX 0.2%	16.5	20.8
	Control: 100/90/90		Control	38.0	54.2
	XP-Bond®		E&R
	CHX 2%: 100/90/85		CHX 2%	14.4	24.2
	CHX 0.2%: 95/100/90		CHX 0.2%	13.1	30.8
	Control: 100/95/85		Control	33.1	64.1