Vitamin D Supplementation for Prevention of Dental Implant Failure: A Systematic Review

Table 3

Data from animal studies.

Author	Title	Study type	Results
Kelly et al., 2008	Vitamin D and bone physiology: Demonstration of vitamin D deficiency in an implant osseointegration rat model	Animal study	Exposed implant surface in vitamin D-deficient rats
Zhou et al., 2012	1,25-Dihydroxy vitamin D3 improves titanium implant osseointegration in osteoporotic rats	Animal study	Increased bone density by 1.2-fold, osseointegration by 1.5-fold, and extrusion force resistance by 2.0-fold in osteoporotic rats. The trabecular bone amount was elevated by 96%, and osseointegration was elevated up to 94.4%. Trabecular number was elevated by 112.5% and 51.8% connective tissue
Wu et al., 2012	Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats	Animal study	Bone volume, osseointegration, trabecular bone number and thickness, connective tissue density, BIC, and push-out force were improved
Akhavan et al., 2012	The effect of vitamin D supplementation on bone formation around titanium implants in diabetic rats	Animal study	No significant effect of vitamin D on osseointegration in diabetic rats
Dvorak et al., 2012	Impact of dietary vitamin D on osseointegration in the ovariectomized rat	Animal study	No significant rescission of the BIC in the medullar and periosteal compartment among rats that received vitamin D when compared to those that did not
Liu et al., 2014	Vitamin D supplementation enhances the fixation of titanium implants in CKD mice	Animal study	A significant difference was observed when vitamin D supplements were given to rats with CKD