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International Journal of Endocrinology
Volume 2009, Article ID 476897, 5 pages
Clinical Study

Oral Contraceptives after Myomectomy: A Short Term Trial

Obstetrics and Gynecology Unit, Department of Pediatrics, Gynecology, and Reproductive Medicine, University of Siena, 53100 Siena, Italy

Received 5 February 2009; Revised 4 May 2009; Accepted 4 June 2009

Academic Editor: Anil K. Agarwal

Copyright © 2009 Stefano Luisi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Following myomectomy the rate of fertility is restored and pregnancy may be attempted with a good outcome. In the present study a 3 month treatment with OCs in a group of women after a myomectomy was evaluated. The drug compliance and side effects, the benefits of OC in order to reduce symptoms, to increase post-surgical hemoglobin levels and to avoid an early pregnancy after myomectomy were analyzed. A group of women ( 𝑛 = 5 5 ) each with myoma 5 cm was recruited: they presented menorrhagia, pelvic pain, dyspareunia and dysmenorrhae. After laparotomic myomectomy the women were divided into 3 groups. Group 1: women ( 𝑛 = 1 6 ) treated with pill A (15 mcg of ethynilestradiol + 60 mcg of gestodene); group 2: women ( 𝑛 = 2 3 ) treated with pill B (20 mcg of ethynilestradiol + 100 mcg of levonorgestrel); group 3: women ( 𝑛 = 1 6 ) treated with a placebo (oral calcium). After three months from myomectomy and treatment patients in each group reported a reduced menorrhagia, dismenorrhea and pelvic pain. Serum haemoglobin levels increased in all women ( 𝑃 < . 0 5 ). No pregnancy occurred in any group and the compliance was good. A post surgery treatment by using oral contraceptives guarentees pregnancy prevention, associated with reduction of pain, and improvement of haematologic conditions.