Article Design Patients Intervention Outcome Limitations Hillman et al. [32 ] Double-blinded RCT 15 children aged 7–13 2000 D3
1 g Ca versus 2000 D3 versus 400 D3
1 g Ca versus 400 D3 for 6 months No change in 25OHD, 1,25OHD levels in any arm Short duration of treatment, small study, young patients only Boyle et al. [9 ] Open label CT 66 adult vitamin D deficient (25OHD
75 nmol/L [30 ng/mL]) patients Sequential efforts of 50,000 IU D2 weekly for 8 weeks or twice weekly for 8 weeks Only 5 (8%) patients achieved repletion (25OHD
75 nmol/L [30 ng/mL]) Many follow up 25OHD levels may have been drawn after supplementation ended. Haworth et al. [37 ] Double-blinded RCT 30 adult patients with BMD z score
1 in lumbar spine, femur or distal forearm 1 g cal
1700 IU D3 (treatment) versus 900 IU D3 (control) over 12 months Treatment group showed reduced rate of bone loss, no significant change in 25OHD level Small sample size, changes in BMD not statistically significant Brown et al. [38 ] Open Label 10 adult CF patients10 healthy patients 5 microg calcitriol bid for 14 days Increased short term study showing improved calcium absorption in both healthy and CF patients. In CF, calcitriol also decreased urine NTX in CF patients. Short duration of treatment, Long term effects unknown. Calcitriol requires close monitoring to prevent hypecalciuria & hypercalcemia Stephenson et al. [35 ] Open Label, dose escalating study 215 CF adults patients with 25OHD
50 nmol/L (20 ng/mL) 400 IU D3, 800 IU D3, 1000 IU D3,
1000 IU D3, compliance counseling 92% achieved 25OHD
50 nmol/L (20 ng/mL) with average dose of 1800 IU/day
75 nmol/L No control group, no differentiation in outcome between intervention arms
Khazai et al. [29 ]
Open label RCT
30 CF adult patients 50,000 IU D2 weekly 100% D3 achieved 25OHD
75 nmol/L (30 ng/mL) Small sample size, limited compliance in sun lamp arm 50,000 IU D3 weekly, 60% D2 achieved 25OHD
75 nmol/L (30 ng/mL) 2%–5% UVB lamps 55% sunlamps achieved 25OHD
75 nmol/L (30 ng/mL)
Green 2008 [71 ] Retrospective chart review 262 pediatric CF patients 50,000 IU D2 1X weekly, 2X weekly or 3X weekly for variable lengths of time 33% weekly achieved 25OHD
75 nmol/L (30 ng/mL)
75 nmol/L (30 ng/mL)
75 nmol/L (30 ng/mL) While there was some improvement in levels, no treatment was significantly better than controls Gronowitz et al. [72 ] Open Label Controlled Trial 30 pts aged 9–40 mean initial 25OHD 53 nmol/L (21.2 ng/mL) in control and 55 nmol/L (22 ng/mL) in treatment at baseline Routine Supplementation (400-2250 IU D3 daily) versus Routine Supplementation + UVB lamps for 12 weeks 25OHD level post 8 weeks: Control 48 nmol/L (19.2 ng/mL) Intervention 110 nmol/L (44 ng/mL) Limited compliance to treatment regimen due to skin type side effects with prolonged UVB exposure
