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International Journal of Endocrinology
Volume 2010 (2010), Article ID 235035, 5 pages
http://dx.doi.org/10.1155/2010/235035
Research Article

Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

1Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
2Department of Pediatrics, Rochester General Hospital, Rochester, NY 14621, USA
3Golisano Children's Hospital, University of Rochester Medical Center, Rochester, NY 14642, USA

Received 25 April 2009; Revised 27 July 2009; Accepted 23 August 2009

Academic Editor: Alan Malabanan

Copyright © 2010 Carol L. Wagner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To examine the effectiveness of oral vitamin D 3 (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants. Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin D 3 /day starting at one month of age. Infant 25(OH)D levels (mean ± S.D.) were measured by RIA at visits 1, 4, and 7. Results. The infant mean ± S.D. 25(OH)D at baseline was 16.0 ± 9.3 ng/mL (range 1.0–40.8; 𝑛 = 3 3 ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 ± 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 ± 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant ( 𝑃 . 0 0 0 1 ) , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 ( 𝑃 = . 6 6 ) . Conclusions. Oral vitamin D 3 supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.