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International Journal of Endocrinology
Volume 2010, Article ID 270832, 12 pages
Review Article

Sleep and Metabolism: An Overview

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Brody School of Medicine, Greenville, 27834 NC, USA

Received 29 September 2009; Revised 2 February 2010; Accepted 28 April 2010

Academic Editor: Jessica A. Mong

Copyright © 2010 Sunil Sharma and Mani Kavuru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sleep and its disorders are increasingly becoming important in our sleep deprived society. Sleep is intricately connected to various hormonal and metabolic processes in the body and is important in maintaining metabolic homeostasis. Research shows that sleep deprivation and sleep disorders may have profound metabolic and cardiovascular implications. Sleep deprivation, sleep disordered breathing, and circadian misalignment are believed to cause metabolic dysregulation through myriad pathways involving sympathetic overstimulation, hormonal imbalance, and subclinical inflammation. This paper reviews sleep and metabolism, and how sleep deprivation and sleep disorders may be altering human metabolism.