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International Journal of Endocrinology
Volume 2010 (2010), Article ID 472173, 7 pages
http://dx.doi.org/10.1155/2010/472173
Review Article

Possible Health Implications and Low Vitamin D Status during Childhood and Adolescence: An Updated Mini Review

12nd Department of Pediatrics, Aristotle University of Thessaloniki, School of Medicine, Ahepa General Hospital, St. Kiriakidi 1, 54636 Thessaloniki, Greece
2Department of Pathology, Aristotle University of Thessaloniki, School of Medicine, Ahepa General Hospital, St. Kiriakidi 1, 54636 Thessaloniki, Greece

Received 31 March 2009; Accepted 17 June 2009

Academic Editor: Suzanne E. Judd

Copyright © 2010 Dimitrios Papandreou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vitamin D deficiency is common in the developing countries and exists in both childhood and adult life. The great importance of Vitamin D is the moderation of calcium (Ca) and phosphorus (P) homeostasis as well as the absorption of Ca. While insufficiency of vitamin D is a significant contributing factor to risk of rickets in childhood, it is possible that a more marginal deficiency of vitamin D during life span contribute to osteoporosis as well as potentially to the development and various other chronic diseases such as cardiovascular disease, cancer and diabetes. This paper reviews the metabolism, epidemiology, and treatment of vitamin D and calcium insufficiency as well as its relation to various diseases during childhood and adolescence.