International Journal of Endocrinology / 2010 / Article / Fig 2

Research Article

Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

Figure 2

The serum creatinine and BUN levels in 5/6 nephrectomized (NX) uremic rats. 5/6 NX rats on normal diet were treated with vehicle, paricalcitol, or doxercalciferol at indicated doses, i.p., 3 times/week, for two weeks ( per group). Sham-vehicle rats were dosed with vehicle. Handling of animals was as described in Materials and Methods. Blood samples were collected for the measurement of serum creatinine and BUN. Mean standard error was calculated for each group. Unpaired t-test with 95% confidence intervals of difference was performed for statistical comparisons. versus Day 0 (before dosing at six weeks after the surgery). Day 13: after dosing with vehicle or drugs.

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