Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats
Figure 3
Effects of paricalcitol and enalapril on blood pressure and heart rate in 5/6 NX rats. SHAM or 5/6 NX rats were treated with vehicle or paricalcitol at 0.042 g/kg as described in “Materials and Methods” ( = 8–10 per group). SHAM rats treated with vehicle were used as control. One group of rats was given enalapril as another control. The arrow sign (Day 0) indicates the initiation of treatment. (a) Mean arterial pressure (MAP), (b) systolic pressure (SP), (c) diastolic pressure (DP), and (d) heart rate. MAP was 156.5 ± 7.8 mmHg in the 5/6 NX rat at Week 7 after surgery (i.e., Day 6 as shown in the graph) versus 107.1 ± 2.0 mmHg in SHAM; SP was 181.0 ± 10.0 versus 127.8 ± 3.8 mmHg; DP was 135.2 ± 6.6 versus 92.2 ± 1.5 mmHg.
