Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2010, Article ID 819414, 6 pages
http://dx.doi.org/10.1155/2010/819414
Research Article

Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats

1Department of Neuroendocrinology, Center for Behavior and Neurosciences, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands
2Department of Behavioral Physiology, Center for Behavior and Neurosciences, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands

Received 16 October 2009; Revised 22 December 2009; Accepted 2 January 2010

Academic Editor: Jessica A. Mong

Copyright © 2010 R. Paulien Barf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epidemiological studies have shown an association between short or disrupted sleep and an increased risk for metabolic disorders. To assess a possible causal relationship, we examined the effects of experimental sleep disturbance on glucose regulation in Wistar rats under controlled laboratory conditions. Three groups of animals were used: a sleep restriction group (RS), a group subjected to moderate sleep disturbance without restriction of sleep time (DS), and a home cage control group. To establish changes in glucose regulation, animals were subjected to intravenous glucose tolerance tests (IVGTTs) before and after 1 or 8 days of sleep restriction or disturbance. Data show that both RS and DS reduce body weight without affecting food intake and also lead to hyperglycemia and decreased insulin levels during an IVGTT. Acute sleep disturbance also caused hyperglycemia during an IVGTT, yet, without affecting the insulin response. In conclusion, both moderate and severe disturbances of sleep markedly affect glucose homeostasis and body weight control.