Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats
Table 1
Effect of various groups of Vinca rosea on serum profile in alloxan (150 mg/kg, i.p.) induced diabetic albino rats after 14 days of treatment.
Groups
Colesterol (mg/dl)
H.D.L(mg/dl)
L.D.L(mg/dl)
Creatinine(mg/dl)
Urea(mg/dl)
Alkaline Phosphatase (mg/dl)
Normal control
145.36 3.2
36.83 2.5
91.32 1.2
0.54 0.3
31.83 2.2
120 3.2
Diabetic control
271.16 10.5
30.00 1.9
189 12.4
2.4 0.1
62.6 1.8
276.00 3.6
Alloxan + Whole plant extract (300 mg/kg,p.o)
184.32 2.5*
34.22 4.3*
120.27 1.4*
0.98 0.3*
43.323.8*
146.35 4.9*
Alloxan + Whole plant extract (500 mg/kg,p.o)
158.46 5.6*
36.63 2.1*
93.65 3.6*
0.60 0.2*
32.332.0*
135.55 4.9*
Alloxan + glibenclamide (5 mg/kg)
145.42 5.3*
36.73 1.5*
92.35 3.1*
0.58 0.1*
31.244.0*
130.75 2.9*
Values are given as mean ± SEM for groups of six animals each *P <.01 (Dunnet -test). Diabetic control was compared with the vehicle control and extract treated groups were compared with the diabetic control.
