Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma

Table 3

RXRA SNPs modify associations between dietary intake frequency of vitamin D rich foods and risk of renal cell carcinoma.

Genotype association

^§Dietary intake of egg

^†Dietary intake of vitamin D rich foods

Wild type

≥1 variant

Wild type

≥1 variant

Cases/Controls

Cases/Controls

Cases/Controls

Cases/Controls

Cases/Controls

SNP

N/N

OR

(LCI-UCI)

Egg

N/N

OR

(LCI-UCI)

N/N

OR

(LCI-UCI)

∗LRT

Vitamin D

N/N

OR

(LCI-UCI)

N/N

OR

(LCI-UCI)

∗LRT

rs1007971 (^∗7453G>𝐶)

Dietary intake of egg

Dietary intake of vitamin D rich foods

CG/CC

293/338

1.00

Low (<33%)

153/231

1.00

119/107

1.00

Low (<33%)

171/234

1.00

113/111

1.00

GG

484/697

0.79

(0.64–0.96)

Medium (33–66%)

251/328

1.27

(0.95–1.69)

143/133

1.05

(0.71–1.54)

Medium (33–66%)

164/239

0.90

(0.67–1.20)

115/114

1.04

(0.70–1.55)

High (>66%)

79/138

0.99

(0.69–1.43)

31/98

0.32

(0.19–0.53)

High (>66%)

148/224

0.90

(0.66–1.25)

65/113

0.63

(0.39–1.00)

̂‌ P-trend

.05

P-trend

.82

<.001

.01

P-trend

.53

.07

0.11

rs3118523 (^∗7060A>𝐺)

Dietary intake of Egg

Dietary intake of vitamin D rich foods

AG/GG

295/321

1.00

Low (<33%)

149/237

1.00

123/101

1.00

Low (<33%)

174/233

1.00

110/112

1.00

AA

482/714

0.72

(0.58–0.88)

Medium (33–66%)

253/331

1.34

(1.01–1.80)

141/130

0.95

(0.64–1.40)

Medium (33–66%)

165/246

0.87

(0.65–1.16)

114/107

1.13

(0.75–1.68)

High (>66%)

79/146

0.98

(0.68–1.42)

31/90

0.29

(0.17–0.49)

High (>66%)

142/235

0.78

(0.57–1.08)

71/102

0.86

(0.54–1.38)

̂‌ P-trend

.01

P-trend

.36

<.001

.01

P-trend

.14

.58

.59

rs748964 (^∗5628C>𝐺)

Dietary intake of egg

Dietary intake of vitamin D rich foods

CG/GG

214/224

1.00

Low (<33%)

180/270

1.00

92/68

1.00

Low (<33%)

207/277

1.00

77/68

1.00

CC

563/811

0.70

(056–0.88)

Medium (33–66%)

291/367

1.26

(0.97–1.64)

103/94

0.91

(0.56–1.46)

Medium (33–66%)

193/263

0.97

(0.74–1.27)

86/90

0.83

(0.52–1.35)

High (>66%)

91/174

0.86

(0.62–1.20)

19/62

0.21

(0.11–0.42)

High (>66%)

162/271

0.82

(0.61–1.11)

51/66

0.69

(0.39–1.24)

̂‌ P-trend

.01

P-trend

.73

<.001

.01

P-trend

.21

.21

.72

rs3118536 (IVS4-542C > A)

Dietary intake of egg

Dietary intake of vitamin D rich foods

AC/AA

259/310

1.00

Low (<33%)

175/250

1.00

97/88

1.00

Low (<33%)

195/248

1.00

89/97

1.00

CC

518/725

0.82

(0.67–1.00)

Medium (33–66%)

263/320

1.25

(0.95–1.65)

131/141

0.90

(0.59–1.37)

Medium (33–66%)

168/235

0.91

(0.68–1.21)

111/118

0.96

(0.64–1.44)

High (>66%)

79/155

0.81

(0.57–1.16)

31/81

0.35

(0.20–0.60)

High (>66%)

154/242

0.86

(0.63–1.17)

59/95

0.65

(0.40–1.06)

̂‌ P-trend

.02

P-trend

.49

<.001

.21

P-trend

.33

.10

.99

rs10776909 (IVS1-4732C > T)

Dietary intake of egg

Dietary intake of vitamin D rich foods

CT/TT

302/372

1.00

Low (<33%)

159/227

1.00

113/111

1.00

Low (<33%)

174/226

1.00

110/119

1.00

CC

475/663

0.86

(0.70–1.04)

Medium (33–66%)

242/291

1.24

(0.93–1.67)

152/170

1.00

(0.69–1.46)

Medium (33–66%)

155/205

1.00

(0.74–1.36)

124/148

0.84

(0.58–1.21)

High (>66%)

73/145

0.78

(0.54–1.13)

37/91

0.44

(0.26–0.72)

High (>66%)

145/232

0.88

( 0.63–1.22)

68/105

0.65

(0.41–1.02)

̂‌ P-trend

.05

P-trend

.37

.004

.37

P-trend

.45

.06

.82

Main effects adjusted for age, sex, study center, and smoking status. Frequency of dietary intake variables categorized into tertiles based on intake among genotyped controls. ^§ Dietary effect adjusted for age, study center, BMI, self-reported hypertensive status, and smoking status.^† Dietary effect adjusted for age, study center, BMI, self-reported hypertensive status, smoking status, and occupational UV exposure.̂‌P-trend based on additive model. ∗ Likelihood Ratio Test.