Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor
DHT induces the tcf8 promoter plasmid in a dose-dependent manner in LNCaP cell line derivatives. The LNCaP (a), C4 (b), C4-2 (c), and C4-2B (d) cell lines were transfected with the pBlueZEB974 promoter plasmid and then cultured with increasing DHT as indicated. The cells were harvested after 24 hrs and the β-galactosidase activity in the lysates was determined. (e) C4-2 cells were transfected with the wild type pBlueZEB974 plasmid or with the plasmids containing one or both AREs mutated. Data are plotted relative to the average with no DHT. , , .
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