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International Journal of Endocrinology
Volume 2011, Article ID 916380, 6 pages
Clinical Study

Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study

Department of Andrology, Ankur Health Care Private Limited, No. 55, 20th Main, 1st Block, Rajajinagar, Bengaluru 560010, India

Received 15 July 2011; Accepted 4 October 2011

Academic Editor: Maria L. Dufau

Copyright © 2011 Vasan Sathya Srini and Srinivas Belur Veerachari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsurgical varicocelectomy, and group 2 (100 patients) underwent assisted reproduction procedures. All participants had semen analysis, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and total testosterone (TT), measured both at recruitment time and 6 months later. In group 1, the mean TT level increased significantly after varicocelectomy ( to  ng/dL, ) and testicular size correlated with the mean change in TT ( ). No similar change was found in group 2. Out of the 100 patients in group 1, 78 had postoperative normalization of TT unlike only 16 men in group 2.