Review Article

Systematic Review of Primary Hyperparathyroidism in India: The Past, Present, and the Future Trends

Table 2

Comparison of biochemical profile in PHPT from various Indian institutes and a center in USA.

Inst: 1 [4, 5] ( 𝑛 = 1 0 0 )Inst: 2 [8] ( 𝑛 = 8 8 )Inst: 3 [6] ( 𝑛 = 4 6 )Inst: 4 [7] ( 𝑛 = 7 9 )Inst: 5 ( 𝑛 = 1 5 ) (unpublished data)USA [33] ( 𝑛 = 1 0 0 0 0 )Comparison of Indian versus USA study*

Serum calcium (2.12–2.49 mmol/l) 3 . 1 4 ± 0 . 4 1 (2.55–4.24) 2 . 9 7 ± 0 . 2 5 2 . 8 ± 0 . 3 3 . 1 1 ± 0 . 4 4 (2.27–4.04) 3 . 2 ± . 3 1 (2.4–4.1) 2 . 7 1 ± . 1 5 𝑃 < . 0 0 1 (with institutes 1, 2, and 4)
𝑃 < . 0 1 (with 3 & 5)
Serum PTH (11–65 pg/mL) 1 0 0 5 . 8 ± 7 6 0 . 3 (66–3250) 6 2 3 ± 7 1 4 8 8 5 . 3 ± 6 1 3 . 2 8 6 6 . 6 ± 6 3 9 . 5 (52–3820) 9 2 6 . 2 ± 7 1 2 . 5 1 0 5 . 8 ± 4 8  pg/mL 𝑃 < . 0 0 1 (with institute 2) 𝑃 < . 0 1 (with 1, 3, 4, &5)
Serum ALP (<150 IU/L) 1 4 6 6 . 5 ± 1 5 4 7 . 6 (98–7240) 4 2 6 ± 5 4 9 NA** 7 6 2 . 2 ± 7 5 4 . 8 (50–4930) 7 8 9 . 1 ± 4 5 2 . 3 NA
Serum Vit D (<20 ng/mL Deficiency) 1 1 . 6 ± 8 . 7 4 (2–44)NANANA 1 2 . 5 ± 6 . 4 5 2 2 . 4 ± 9 𝑃 < . 0 0 1 (with institutes 1 & 5)

Indian institutes: institute 1: SGPGIMS, Lucknow; institute 2: CMC Vellore; institute 3: PGIMER Chandigarh; institute 4: KEM Mumbai; institute 5: NMCH Nellore.
*Inferential statistics between groups was performed using one-way ANOVA, followed by Newman-Keuls multiple comparison test.
**NA: Not available.