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International Journal of Endocrinology
Volume 2012, Article ID 109797, 6 pages
Clinical Study

Role of Surrogate Markers of Atherosclerosis in Clinical and Subclinical Thyroidism

1Department of Internal Medicine, Kahramanmaras University, 46000 Kahramanmaras, Turkey
2Department of Internal Medicine, Malatya Hekimhan State Hospital, 44400 Malatya, Turkey
3Division of Nephrology, Yozgat State Hospital, 66000 Yozgat, Turkey
4Department of Radiology, Kahramanmaras University, 46000 Kahramanmaras, Turkey

Received 29 July 2011; Accepted 30 November 2011

Academic Editor: Dariush Elahi

Copyright © 2012 Mehmet Gunduz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Data on the relationship between homocysteine, plasminogen activator inhibitor 1, hs-CRP, fibrinogen, and carotid intima media thickness (CA-IMT) is plenty but contradicting and the majority of the studies investigated this issue in only specific thyroidism groups. The aim of this paper was to investigate these relations in patients with subclinical and clinical hypo- and hyperthyroidism. Methods. In this cross-sectional study, 16 patients from each thyroidism group and 20 healthy cases were enrolled. Fibrinogen levels and plasminogen activator inhibitor 1 (PAI-1) activity were assessed. CA-IMT was determined by gray-scale high-resolution color Doppler ultrasound. Results. Serum homocysteine levels were higher in hypothyroidic patients compared to the control ( 𝑃 = 0 . 0 0 3 ). Fibrinogen levels were higher in patients with subclinical hypothyroidism compared to other groups ( 𝑃 < 0 . 0 5 ). There was no difference between groups regarding PAI-1. Whereas total cholesterol, homocysteine, and LDL were correlated with CAIMT, hs-CRP, PAI-1, and fibrinogen were not. In the clinical hypothyroidism group, the correlation of homocysteine with CA-IMT was derived from the correlation between CA-IMT and homocysteine. Conclusions. Homocysteine and fibrinogen levels are higher in patients with clinical and subclinical hypothyroidism, respectively. Homocysteine level is associated with CA-IMTonly in patients with clinical hypothyroidism.