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International Journal of Endocrinology
Volume 2012 (2012), Article ID 127362, 10 pages
http://dx.doi.org/10.1155/2012/127362
Review Article

Sarcopenia and Age-Related Endocrine Function

1Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1-1 Hibarigaoka, Tenpaku-cho, Toyohashi 441-8580, Japan
2School of Dentistry, Health Sciences University of Hokkaido, Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan

Received 1 December 2011; Accepted 22 February 2012

Academic Editor: Huan Cai

Copyright © 2012 Kunihiro Sakuma and Akihiko Yamaguchi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. J. Melton III, S. Khosla, C. S. Crowson, M. K. O'Connor, W. M. O'Fallon, and B. L. Riggs, “Epidemiology of sarcopenia,” Journal of the American Geriatrics Society, vol. 48, no. 6, pp. 625–630, 2000. View at Google Scholar · View at Scopus
  2. R. N. Baumgartner, D. L. Waters, D. Gallagher, J. E. Morley, and P. J. Garry, “Predictors of skeletal muscle mass in elderly men and women,” Mechanisms of Ageing and Development, vol. 107, no. 2, pp. 123–136, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. K. R. Short and K. S. Nair, “The effect of age on protein metabolism,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 3, no. 1, pp. 39–44, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. K. R. Short, J. L. Vittone, M. L. Bigelow, D. N. Proctor, and K. S. Nair, “Age and aerobic exercise training effects on whole body and muscle protein metabolism,” American Journal of Physiology, vol. 286, no. 1, pp. E92–E101, 2004. View at Google Scholar · View at Scopus
  5. J. Lexell, “Human aging, muscle mass, and fiber type composition,” Journals of Gerontology, vol. 50, pp. 11–16, 1995. View at Google Scholar · View at Scopus
  6. J. Lexell, “Ageing and human muscle: observations from Sweden,” Canadian Journal of Applied Physiology, vol. 18, no. 1, pp. 2–18, 1993. View at Google Scholar · View at Scopus
  7. R. Roubenoff and V. A. Hughes, “Sarcopenia: current concepts,” Journals of Gerontology, vol. 55, no. 12, pp. M716–M724, 2000. View at Google Scholar · View at Scopus
  8. K. Sakuma, M. Akiho, H. Nakashima, H. Akima, and M. Yasuhara, “Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles,” Biochimica et Biophysica Acta, vol. 1782, no. 7–8, pp. 453–461, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Sakuma and A. Yamaguchi, “Molecular mechanisms in aging and current strategies to counteract sarcopenia,” Current Aging Science, vol. 3, no. 2, pp. 90–101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Sakuma and A. Yamaguchi, “Sarcopenia: molecular mechanisms and current therapeutic strategy,” in Cell Aging, pp. 93–152, Nova Science, New York, NY, USA, 2011. View at Google Scholar
  11. D. M. Thomson and S. E. Gordon, “Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle,” Journal of Physiology, vol. 574, no. 1, pp. 291–305, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Degens, “The role of systemic inflammation in age-related muscle weakness and wasting,” Scandinavian Journal of Medicine and Science in Sports, vol. 20, no. 1, pp. 28–38, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. D. Grounds, “Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling,” Biogerontology, vol. 3, no. 1–2, pp. 19–24, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. L. A. Schaap, S. M. F. Pluijm, D. J. H. Deeg, and M. Visser, “Inflammatory markers and loss of muscle mass (sarcopenia) and strength,” American Journal of Medicine, vol. 119, no. 6, pp. 526.e9–526.e17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Drey, “Sarcopenia-pathophysiology and clinical relevance,” Wiener Medizinische Wochenschrift, vol. 161, no. 17–18, pp. 402–408, 2011. View at Google Scholar
  16. K. Sakuma and A. Yamaguchi, “Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass,” Journal of Cachexia, Sarcopenia and Muscle. In press. View at Publisher · View at Google Scholar
  17. F. R. Sattler, C. Castaneda-Sceppa, E. F. Binder et al., “Testosterone and growth hormone improve body composition and muscle performance in older men,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 6, pp. 1991–2001, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. D. R. Thomas, “Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia,” Clinical Nutrition, vol. 26, no. 4, pp. 389–399, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Giovannini, E. Marzetti, S. E. Borst, and C. Leeuwenburgh, “Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults,” Mechanisms of Ageing and Development, vol. 129, no. 10, pp. 593–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Nass, G. Johannsson, J. S. Christiansen, J. J. Kopchick, and M. O. Thorner, “The aging population—is there a role for endocrine interventions?” Growth Hormone and IGF Research, vol. 19, no. 2, pp. 89–100, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Roubenoff, “Catabolism of aging: is it an inflammatory process?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 6, no. 3, pp. 295–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. L. A. Schaap, S. M. F. Pluijm, D. J. H. Deeg et al., “Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength,” Journals of Gerontology, vol. 64, no. 11, pp. 1183–1189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Rieu, H. Magne, I. Savary-Auzeloux et al., “Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats,” Journal of Physiology, vol. 587, no. 22, pp. 5483–5492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Y. Chung, M. Cesari, S. Anton et al., “Molecular inflammation: underpinnings of aging and age-related diseases,” Ageing Research Reviews, vol. 8, no. 1, pp. 18–30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. B. Reid and Y. P. Li, “Tumor necrosis factor-α and muscle wasting: a cellular perspective,” Respiratory Research, vol. 2, no. 5, pp. 269–272, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Aoi and K. Sakuma, “Oxidative stress and skeletal muscle dysfunction with aging,” Current Aging Science, vol. 4, no. 2, pp. 101–109, 2011. View at Google Scholar
  27. S. J. Meng and L. J. Yu, “Oxidative stress, molecular inflammation and sarcopenia,” International Journal of Molecular Sciences, vol. 11, no. 4, pp. 1509–1526, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Bar-Shai, E. Carmeli, R. Coleman et al., “The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-κB in muscles of young and old rats,” Mechanisms of Ageing and Development, vol. 126, no. 2, pp. 289–297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Philips and C. Leeuwenburgh, “Muscle fiber specific apoptosis and TNF-α signaling in sarcopenia are attenuated by life-long calorie restriction,” The FASEB Journal, vol. 19, no. 6, pp. 668–670, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Marzetti, C. S. Carter, S. E. Wohlgemuth et al., “Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction,” Mechanisms of Ageing and Development, vol. 130, no. 4, pp. 272–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. E. E. Pistilli, J. R. Jackson, and S. E. Alway, “Death receptor-associated pro-apoptotic signaling in aged skeletal muscle,” Apoptosis, vol. 11, no. 12, pp. 2115–2126, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. S. J. Lee, “Regulation of muscle mass by myostatin,” Annual Review of Cell and Developmental Biology, vol. 20, pp. 61–86, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. T. A. Zimmers, M. V. Davies, L. G. Koniaris et al., “Induction of cachexia in mice by systemically administered myostatin,” Science, vol. 296, no. 5572, pp. 1486–1488, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. N. M. Wolfman, A. C. McPherron, W. N. Pappano et al., “Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 26, pp. 15842–15846, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Langley, M. Thomas, A. Bishop, M. Sharma, S. Gilmour, and R. Kambadur, “Myostatin inhibits myoblast differentiation by down-regulating MyoD expression,” Journal of Biological Chemistry, vol. 277, no. 51, pp. 49831–49840, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Thomas, B. Langley, C. Berry et al., “Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation,” Journal of Biological Chemistry, vol. 275, no. 51, pp. 40235–40243, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. W. Yang, Y. Zhang, Y. Li, Z. Wu, and D. Zhu, “Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3β pathway and is antagonized by insulin-like growth factor 1,” Journal of Biological Chemistry, vol. 282, no. 6, pp. 3799–3808, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. D. L. Allen and T. G. Unterman, “Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors,” American Journal of Physiology, vol. 292, no. 1, pp. C188–C199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. A. U. Trendelenburg, A. Meyer, D. Rohner, J. Boyle, S. Hatakeyama, and D. J. Glass, “Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size,” American Journal of Physiology, vol. 296, no. 6, pp. C1258–C1270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Sartori, G. Milan, M. Patron et al., “Smad2 and 3 transcription factors control muscle mass in adulthood,” American Journal of Physiology, vol. 296, no. 6, pp. C1248–C1257, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. N. K. LeBrasseur, T. M. Schelhorn, B. L. Bernardo, P. G. Cosgrove, P. M. Loria, and T. A. Brown, “Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice,” Journals of Gerontology, vol. 64, no. 9, pp. 940–948, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. K. T. Murphy, R. Koopman, T. Naim et al., “Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function,” The FASEB Journal, vol. 24, no. 11, pp. 4433–4442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Ratkevicius, A. Joyson, I. Selmer et al., “Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men,” Journals of Gerontology, vol. 66, no. 6, pp. 620–626, 2011. View at Google Scholar
  44. A. A. Ferrando, C. A. Stuart, M. Sheffield-Moore, and R. R. Wolfe, “Inactivity amplifies the catabolic response of skeletal muscle to cortisol,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 10, pp. 3515–3521, 1999. View at Google Scholar · View at Scopus
  45. E. Carballo-Jane, S. Pandit, J. C. Santoro et al., “Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation,” Journal of Steroid Biochemistry and Molecular Biology, vol. 88, no. 2, pp. 191–201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  46. J. M. Sacheck, A. Ohtsuka, S. C. McLary, and A. L. Goldberg, “IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1,” American Journal of Physiology, vol. 287, no. 4, pp. E591–E601, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Dardevet, C. Sornet, D. Taillandier, I. Savary, D. Attaix, and J. Grizard, “Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging,” Journal of Clinical Investigation, vol. 96, no. 5, pp. 2113–2119, 1995. View at Google Scholar · View at Scopus
  48. I. Savary, E. Debras, D. Dardevet et al., “Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats,” British Journal of Nutrition, vol. 79, no. 3, pp. 297–304, 1998. View at Publisher · View at Google Scholar · View at Scopus
  49. I. Rieu, C. Sornet, J. Grizard, and D. Dardevet, “Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats,” Experimental Gerontology, vol. 39, no. 9, pp. 1315–1321, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. W. B. Ershler and E. T. Keller, “Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty,” Annual Review of Medicine, vol. 51, pp. 245–270, 2000. View at Publisher · View at Google Scholar · View at Scopus
  51. K. S. Krabbe, M. Pedersen, and H. Bruunsgaard, “Inflammatory mediators in the elderly,” Experimental Gerontology, vol. 39, no. 5, pp. 687–699, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. A. R. Cappola, Q. L. Xue, L. Ferrucci, J. M. Guralnik, S. Volpato, and L. P. Fried, “Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 5, pp. 2019–2025, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. D. R. Taaffe, T. B. Harris, L. Ferrucci, J. Rowe, and T. E. Seeman, “Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging,” Journals of Gerontology, vol. 55, no. 12, pp. M709–M715, 2000. View at Google Scholar · View at Scopus
  54. M. Hamer and G. J. Molloy, “Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing,” Age, vol. 31, no. 3, pp. 171–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. F. Haddad, F. Zaldivar, D. M. Cooper, and G. R. Adams, “IL-6-induced skeletal muscle atrophy,” Journal of Applied Physiology, vol. 98, no. 3, pp. 911–917, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. M. L. Kohut, D. A. McCann, D. W. Russell et al., “Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults,” Brain, Behavior, and Immunity, vol. 20, no. 3, pp. 201–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. L. K. Stewart, M. G. Flynn, W. W. Campbell et al., “The influence of exercise training on inflammatory cytokines and C-reactive protein,” Medicine and Science in Sports and Exercise, vol. 39, no. 10, pp. 1714–1719, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. H. A. Feldman, C. Longcope, C. A. Derby et al., “Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 2, pp. 589–598, 2002. View at Publisher · View at Google Scholar · View at Scopus
  59. J. E. Morley, F. E. Kaiser, H. M. Perry et al., “Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men,” Metabolism, vol. 46, no. 4, pp. 410–413, 1997. View at Publisher · View at Google Scholar · View at Scopus
  60. J. E. Morley and H. M. Perry, “Androgens and women at the menopause and beyond,” Journals of Gerontology, vol. 58, no. 5, pp. M409–M416, 2003. View at Google Scholar · View at Scopus
  61. R. J. Urban, Y. H. Bodenburg, C. Gilkison et al., “Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis,” American Journal of Physiology, vol. 269, no. 5, pp. E820–E826, 1995. View at Google Scholar · View at Scopus
  62. S. Bhasin, L. Woodhouse, and T. W. Storer, “Proof of the effect of testosterone on skeletal muscle,” Journal of Endocrinology, vol. 170, no. 1, pp. 27–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. V. Bakhshi, M. Elliott, A. Gentili, M. Godschalk, and T. Mulligan, “Testosterone improves rehabilitation outcomes in ill older men,” Journal of the American Geriatrics Society, vol. 48, no. 5, pp. 550–553, 2000. View at Google Scholar · View at Scopus
  64. A. A. Ferrando, M. Sheffield-Moore, C. W. Yeckel et al., “Testosterone administration to older men improves muscle function: molecular and physiological mechanisms,” American Journal of Physiology, vol. 282, no. 3, pp. E601–E607, 2002. View at Google Scholar · View at Scopus
  65. J. E. Morley and H. M. Perry III, “Androgen deficiency in aging men: role of testosterone replacement therapy,” Journal of Laboratory and Clinical Medicine, vol. 135, no. 5, pp. 370–378, 2000. View at Google Scholar · View at Scopus
  66. P. J. Snyder, H. Peachey, P. Hannoush et al., “Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 8, pp. 2647–2653, 1999. View at Google Scholar · View at Scopus
  67. S. Bhasin, O. M. Calof, T. W. Storer et al., “Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging,” Nature Clinical Practice Endocrinology and Metabolism, vol. 2, no. 3, pp. 146–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  68. I. Sinha-Hikim, M. Cornford, H. Gaytan, M. L. Lee, and S. Bhasin, “Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 3024–3033, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. S. Mudali and A. S. Dobs, “Effects of testosterone on body composition of the aging male,” Mechanisms of Ageing and Development, vol. 125, no. 4, pp. 297–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. R. P. Cadilla and P. Turnbull, “Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential,” Current Topics in Medicinal Chemistry, vol. 6, no. 3, pp. 245–270, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. F. Labrie, V. Luu-The, A. Bélanger et al., “Is dehydroepiandrosterone a hormone?” Journal of Endocrinology, vol. 187, no. 2, pp. 169–196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  72. E. E. Baulieu, G. Thomas, S. Legrain et al., “Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge study to a sociobiomedical issue,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 8, pp. 4279–4284, 2000. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Dayal, M. D. Sammel, J. Zhao, A. C. Hummel, K. Vandenbourne, and K. T. Barnhart, “Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids,” Journal of Women's Health, vol. 14, no. 5, pp. 391–400, 2005. View at Publisher · View at Google Scholar · View at Scopus
  74. T. A. C. M. Van Geel, P. P. Geusen, B. Winkens, J. P. J. E. Sels, and G. J. Dinant, “Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study,” European Journal of Endocrinology, vol. 160, no. 4, pp. 681–687, 2009. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Iannuzzi-Sucich, K. M. Prestwood, and A. M. Kenny, “Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women,” Journals of Gerontology, vol. 57, no. 12, pp. M772–M777, 2002. View at Google Scholar · View at Scopus
  76. R. N. Baumgartner, D. L. Waters, D. Gallagher, J. E. Morley, and P. J. Garry, “Predictors of skeletal muscle mass in elderly men and women,” Mechanisms of Ageing and Development, vol. 107, no. 2, pp. 123–136, 1999. View at Publisher · View at Google Scholar · View at Scopus
  77. R. Roubenoff, “Catabolism of aging: is it an inflammatory process?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 6, no. 3, pp. 295–299, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. M. Brown, “Skeletal muscle and bone: effect of sex steroids and aging,” Advances in Physiology Education, vol. 32, no. 2, pp. 120–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  79. R. T. Falk, S. C. Rossi, T. R. Fears et al., “A new ELISA kit for measuring urinary 2-hydroxyestrone, 16α-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid,” Cancer Epidemiology Biomarkers and Prevention, vol. 9, no. 1, pp. 81–87, 2000. View at Google Scholar · View at Scopus
  80. J. R. Florini, D. Z. Ewton, and S. A. Coolican, “Growth hormone and the insulin-like growth factor system in myogenesis,” Endocrine Reviews, vol. 17, no. 5, pp. 481–517, 1996. View at Publisher · View at Google Scholar · View at Scopus
  81. K. Y. Ho, J. D. Veldhuis, M. L. Johnson et al., “Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man,” Journal of Clinical Investigation, vol. 81, no. 4, pp. 968–975, 1988. View at Google Scholar · View at Scopus
  82. A. Giustina, G. Mazziotti, and E. Canalis, “Growth hormone, insulin-like growth factors, and the skeleton,” Endocrine Reviews, vol. 29, no. 5, pp. 535–559, 2008. View at Publisher · View at Google Scholar · View at Scopus
  83. A. Moran, D. R. Jacobs, J. Steinberger et al., “Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 10, pp. 4817–4820, 2002. View at Publisher · View at Google Scholar · View at Scopus
  84. M. Hermann and P. Berger, “Hormonal changes in aging men: a therapeutic indication?” Experimental Gerontology, vol. 36, no. 7, pp. 1075–1082, 2001. View at Publisher · View at Google Scholar · View at Scopus
  85. J. G. Ryall, J. D. Schertzer, and G. S. Lynch, “Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness,” Biogerontology, vol. 9, no. 4, pp. 213–228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  86. J. D. Veldhuis and A. Iranmanesh, “Physiological regulation of the human growth hormone (GH)-insulin-like growth factor type I (IGF-I) axis: predominant impact of age, obesity, gonadal function, and sleep,” Sleep, vol. 19, no. 10, pp. S221–S224, 1996. View at Google Scholar · View at Scopus
  87. D. Le Roith, C. Bondy, S. Yakar, J. L. Liu, and A. Butler, “The somatomedin hypothesis,” Endocrine Reviews, vol. 22, no. 1, pp. 53–74, 2001. View at Publisher · View at Google Scholar · View at Scopus
  88. N. B. Andersen, T. T. Andreassen, H. Orskov, and H. Oxlund, “Growth hormone and mild exercise in combination increases markedly muscle mass and tetanic tension in old rats,” European Journal of Endocrinology, vol. 143, no. 3, pp. 409–418, 2000. View at Google Scholar · View at Scopus
  89. M. R. Blackman, J. D. Sorkin, T. Münzer et al., “Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial,” Journal of the American Medical Association, vol. 288, no. 18, pp. 2282–2292, 2002. View at Publisher · View at Google Scholar · View at Scopus
  90. M. G. Giannoulis, P. H. Sonksen, M. Umpleby et al., “The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 2, pp. 477–484, 2006. View at Publisher · View at Google Scholar · View at Scopus
  91. T. J. Marcell, S. M. Harman, R. J. Urban, D. D. Metz, B. D. Rodgers, and M. R. Blackman, “Comparison of GH, IGF-I, and testosterone with mRNA of receptors and myostatin in skeletal muscle in older men,” American Journal of Physiology, vol. 281, no. 6, pp. E1159–E1164, 2001. View at Google Scholar · View at Scopus
  92. L. Ferrucci, B. W. J. H. Penninx, S. Volpato et al., “Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels,” Journal of the American Geriatrics Society, vol. 50, no. 12, pp. 1947–1954, 2002. View at Publisher · View at Google Scholar · View at Scopus
  93. A. Philippou, M. Maridaki, A. Halapas, and M. Koutsilieris, “The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology,” In Vivo, vol. 21, no. 1, pp. 45–54, 2007. View at Google Scholar · View at Scopus
  94. G. E. Butterfield, J. Thompson, M. J. Rennie, R. Marcus, R. L. Hintz, and A. R. Hoffman, “Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women,” American Journal of Physiology, vol. 272, no. 1, pp. E94–E99, 1997. View at Google Scholar · View at Scopus
  95. W. J. Evans, G. Paolisso, A. M. Abbatecola et al., “Frailty and muscle metabolism dysregulation in the elderly,” Biogerontology, vol. 11, no. 5, pp. 527–536, 2010. View at Publisher · View at Google Scholar · View at Scopus
  96. D. Dardevet, C. Sornet, D. Attaix, V. E. Baracos, and J. Grizard, “Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats,” Endocrinology, vol. 134, no. 3, pp. 1475–1484, 1994. View at Publisher · View at Google Scholar · View at Scopus
  97. L. C. Martineau, S. G. Chadan, and W. S. Parkhouse, “Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse,” Mechanisms of Ageing and Development, vol. 106, no. 3, pp. 217–232, 1999. View at Publisher · View at Google Scholar · View at Scopus
  98. E. Arvat, F. Broglio, and E. Ghigo, “Insulin-like growth factor I: implications in aging,” Drugs and Aging, vol. 16, no. 1, pp. 29–40, 2000. View at Google Scholar · View at Scopus
  99. E. A. Wilkes, A. L. Selby, P. J. Atherton et al., “Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia,” American Journal of Clinical Nutrition, vol. 90, no. 5, pp. 1343–1350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  100. M. Kojima and K. Kangawa, “Ghrelin: structure and function,” Physiological Reviews, vol. 85, no. 2, pp. 495–522, 2005. View at Publisher · View at Google Scholar · View at Scopus
  101. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, vol. 402, no. 6762, pp. 656–660, 1999. View at Publisher · View at Google Scholar · View at Scopus
  102. V. D. Dixit, E. M. Schaffer, R. S. Pyle et al., “Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells,” Journal of Clinical Investigation, vol. 114, no. 1, pp. 57–66, 2004. View at Publisher · View at Google Scholar · View at Scopus
  103. T. Akamizu and K. Kangawa, “Ghrelin for cachexia,” Journal of Cachexia, Sarcopenia, and Muscle, vol. 1, no. 2, pp. 169–176, 2010. View at Publisher · View at Google Scholar
  104. N. Nagaya, T. Itoh, S. Murakami et al., “Treatment of cachexia with ghrelin in patients with COPD,” Chest, vol. 128, no. 3, pp. 1187–1193, 2005. View at Publisher · View at Google Scholar · View at Scopus
  105. N. Nagaya, J. Moriya, Y. Yasumura et al., “Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure,” Circulation, vol. 110, no. 24, pp. 3674–3679, 2004. View at Publisher · View at Google Scholar · View at Scopus
  106. M. A. Bach, K. Rockwood, C. Zetterberg et al., “The Effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture,” Journal of the American Geriatrics Society, vol. 52, no. 4, pp. 516–523, 2004. View at Publisher · View at Google Scholar · View at Scopus
  107. M. F. Holick, “Vitamin D deficiency,” New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  108. H. F. DeLuca, “Overview of general physiologic features and functions of vitamin D,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1689S–1696S, 2004. View at Google Scholar · View at Scopus
  109. F. M. Gloth III, C. M. Gundberg, B. W. Hollis, J. G. Haddad, and J. D. Tobin, “Vitamin D deficiency in homebound elderly persons,” Journal of the American Medical Association, vol. 274, no. 21, pp. 1683–1686, 1995. View at Google Scholar · View at Scopus
  110. D. Goldray, E. Mizrahi-Sasson, C. Merdler et al., “Vitamin D deficiency in elderly patients in a general hospital,” Journal of the American Geriatrics Society, vol. 37, no. 7, pp. 589–592, 1989. View at Google Scholar · View at Scopus
  111. I. S. Wicherts, N. M. Van Schoor, A. J. P. Boeke et al., “Vitamin D status predicts physical performance and its decline in older persons,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2058–2065, 2007. View at Publisher · View at Google Scholar · View at Scopus
  112. H. A. Bischoff-Ferrari, M. Borchers, F. Gudat, U. Dürmüller, H. B. Stähelin, and W. Dick, “Vitamin D receptor expression in human muscle tissue decreases with age,” Journal of Bone and Mineral Research, vol. 19, no. 2, pp. 265–269, 2004. View at Google Scholar
  113. Y. Sato, J. Iwamoto, T. Kanoko, and K. Satoh, “Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial,” Cerebrovascular Diseases, vol. 20, no. 3, pp. 187–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  114. M. Montero-Odasso and G. Duque, “Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone,” Molecular Aspects of Medicine, vol. 26, no. 3, pp. 203–219, 2005. View at Publisher · View at Google Scholar · View at Scopus
  115. S. Yoshikawa, T. Nakamura, H. Tanabe, and T. Imamura, “Osteomalacic myopathy,” Endocinological Japan, vol. 26, pp. 65–72, 1979. View at Google Scholar
  116. O. H. Sorensen, Lund Bi., and B. Saltin, “Myopathy in bone loss of ageing: improvement by treatment with 1α-hydroxycholecalciferol and calcium,” Clinical Science, vol. 56, no. 2, pp. 157–161, 1979. View at Google Scholar · View at Scopus
  117. K. A. Faulkner, J. A. Cauley, J. M. Zmuda et al., “Higher 1, 25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women,” Osteoporosis International, vol. 17, no. 9, pp. 1318–1328, 2006. View at Publisher · View at Google Scholar · View at Scopus
  118. L. Flicker, K. Mead, R. J. MacInnis et al., “Serum vitamin D and falls in older women in residential care in Australia,” Journal of the American Geriatrics Society, vol. 51, no. 11, pp. 1533–1538, 2003. View at Publisher · View at Google Scholar · View at Scopus
  119. M. B. Snijder, N. M. Van Schoor, S. M. F. Pluijm, R. M. Van Dam, M. Visser, and P. Lips, “Vitamin D status in relation to one-year risk of recurrent falling in older men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 2980–2985, 2006. View at Publisher · View at Google Scholar · View at Scopus
  120. C. Annweiler, A. M. Schott, G. Berrut, B. Fantino, and O. Beauchet, “Vitamin D-related changes in physical performance: a systematic review,” Journal of Nutrition, Health and Aging, vol. 13, no. 10, pp. 893–898, 2009. View at Publisher · View at Google Scholar · View at Scopus
  121. H. A. Bischoff-Ferrari, B. Dawson-Hughes, H. B. Staehelin et al., “Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials,” British Medical Journal, vol. 339, p. b3692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  122. L. Ceglia, “Vitamin D and its role in skeletal muscle,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 6, pp. 628–633, 2009. View at Publisher · View at Google Scholar · View at Scopus
  123. B. Dawson-Hughes, “Serum 25-hydroxyvitamin D and functional outcomes in the elderly,” American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 537S–540S, 2008. View at Google Scholar · View at Scopus
  124. M. Pfeifer, B. Begerow, H. W. Minne, K. Suppan, A. Fahrleitner-Pammer, and H. Dobnig, “Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals,” Osteoporosis International, vol. 20, no. 2, pp. 315–322, 2009. View at Publisher · View at Google Scholar · View at Scopus
  125. C. Jackson, S. Gaugris, S. S. Sen, and D. Hosking, “The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis,” Quarterly Journal of Medicine, vol. 100, no. 4, pp. 185–192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  126. N. K. Latham, C. S. Anderson, and I. R. Reid, “Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review,” Journal of the American Geriatrics Society, vol. 51, no. 9, pp. 1219–1226, 2003. View at Publisher · View at Google Scholar · View at Scopus
  127. K. M. Sanders, A. L. Stuart, E. J. Williamson et al., “Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial,” Journal of the American Medical Association, vol. 303, no. 18, pp. 1815–1822, 2010. View at Publisher · View at Google Scholar · View at Scopus
  128. M. Cesari, R. A. Incalzi, V. Zamboni, M. Pahor et al., “Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons,” Geriatrics and Gerontology International, vol. 11, no. 2, pp. 133–142, 2011. View at Publisher · View at Google Scholar