Application of the New Classification on Patients with a Disorder of Sex Development in Indonesia

Table 3

Additional clinical data in patients with known histology results.

Number	Age	Gender	Karyotype	Quigley stage	Hormonal analysis	Imaging	Surgery	Mutation	Histology	Diagnosis
1	33	Female	46 XY	4	Very high testosterone with slightly increased values of gonadotropins	No abnormalities	Laparoscopy	No	Ovarian Leydig cell tumor lacking histological signs of malignancy	Disorder of androgen excess
2	23	Female	46 XY	6	High basal testosterone level	No abnormalities	Gonadectomy	AR neg	Leydic cell hyperplasia and atrophy of most seminiferous tubules but no evidence of CIS	Disorder of androgen action
3	13	Male	46 XY	3	High basal testosterone level	Gonads not in situ* no uterus and adnexa 1/3 vagina present	Laparoscopy gonadectomy	AR neg	CIS	PAIS
4	3	Male	46 XX/XY	2	hCG test: good response testosterone	No abnormalities	Gonadectomy	SRY neg	Ovarian tissue with multiple cysts including primordial follicles and granulosa cells	Gonadal dysgenesis

*Gonads already removed before ultrasound.