International Journal of Endocrinology
Volume 2012 (2012), Article ID 469235, 10 pages
http://dx.doi.org/10.1155/2012/469235
Aging and Bone Health in Individuals with Developmental Disabilities
1Metabolism Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
2Department of Neurology and Neurodevelopment, Kennedy Krieger Institute, 801 N. Broadway, Baltimore, MD 21224, USA
3Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
Received 30 March 2012; Accepted 17 May 2012
Academic Editor: Huan Cai
Copyright © 2012 Joan Jasien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- Centers for Disease Control, http://www.cdc.gov/ncbddd/dd/default.htm.
- American Association on Intellectual and Developmental Disabilities, http://www.aaidd.org/intellectualdisabilitybook/content_7473.cfm?navID=366.
- G. Carter and J. Jancar, “Mortality in the mentally handicapped: a 50 year survey at the Stoke Park group of hospitals (1930–1980),” Journal of Mental Deficiency Research, vol. 27, no. 2, pp. 143–156, 1983. View at Google Scholar · View at Scopus
- M. P. Janicki, A. J. Dalton, C. M. Henderson, and P. W. Davidson, “Mortality and morbidity among older adults with intellectual disability: health services considerations,” Disability and Rehabilitation, vol. 21, no. 5-6, pp. 284–294, 1999. View at Publisher · View at Google Scholar · View at Scopus
- Q. Yang, S. A. Rasmussen, and J. M. Friedman, “Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study,” The Lancet, vol. 359, no. 9311, pp. 1019–1025, 2002. View at Publisher · View at Google Scholar · View at Scopus
- T. Fryers, “Survival in Down's syndrome,” Journal of Mental Deficiency Research, vol. 30, no. 2, pp. 101–110, 1986. View at Google Scholar · View at Scopus
- Q. Malone, “Mortality and survival of the Down's syndrome population in Western Australia,” Journal of Mental Deficiency Research, vol. 32, no. 1, pp. 59–65, 1988. View at Google Scholar · View at Scopus
- King's Fund, “An Ordinary Life-Comprehensive Locally-based Services for People with Mental Handicaps, King's Fund Project Paper No. 50,” King's Fund Centre, London, UK, 1980.
- A. H. Bittles, B. A. Petterson, S. G. Sullivan, R. Hussain, E. J. Glasson, and P. D. Montgomery, “The influence of intellectual disability on life expectancy,” Journals of Gerontology—Series A, vol. 57, no. 7, pp. M470–M472, 2002. View at Google Scholar · View at Scopus
- K. Patja, M. Iivanainen, H. Vesala, H. Oksanen, and I. Ruoppila, “Life expectancy of people with intellectual disability: a 35-year follow-up study,” Journal of Intellectual Disability Research, vol. 44, no. 5, pp. 591–599, 2000. View at Publisher · View at Google Scholar · View at Scopus
- E. A. Perkins and J. Moran, “Aging adults with intellectual disabilities,” The Journal of the American Medical Association, vol. 304, no. 1, pp. 91–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
- T. Heller, “Report of the state of the science in aging with developmental disabilities: charting lifespan trajectories and supportive environments for healthy community living symposium,” Disability and Health Journal, vol. 1, no. 3, pp. 127–130, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. Pietschmann, M. Rauner, W. Sipos, and K. Kerschan-Schindl, “Osteoporosis: an age-related and gender-specific disease—a mini-review,” Gerontology, vol. 55, no. 1, pp. 3–12, 2009. View at Publisher · View at Google Scholar · View at Scopus
- B. L. Riggs, S. Khosla, and L. J. Melton III, “Sex steroids and the construction and conservation of the adult skeleton,” Endocrine Reviews, vol. 23, no. 3, pp. 279–302, 2002. View at Publisher · View at Google Scholar · View at Scopus
- C. A. Lee and T. A. Einhorn, “The bone organ system: form and function,” in Osteroporosis, R. Marcus, D. Feldman, and J. Kelsey, Eds., pp. 2–20, Academic Press, Salt Lake City, Utah, USA, 2nd edition, 2001. View at Google Scholar
- F. A. Syed and A. C. Ng, “The pathophysiology of the aging skeleton,” Current Osteoporosis Reports, vol. 8, no. 4, pp. 235–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. P. Geusens, “Review of guidelines for testing and treatment of osteoporosis,” Current Osteoporosis Reports, vol. 1, no. 2, pp. 59–65, 2003. View at Google Scholar · View at Scopus
- S. van Helden, A. C. M. van Geel, P. P. Geusens, A. Kessels, A. C. N. Kruseman, and P. R. G. Brink, “Bone and fall-related fracture risks in women and men with a recent clinical fracture,” The Journal of Bone and Joint Surgery—Series A, vol. 90, no. 2, pp. 241–248, 2008. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Rao and M. D. Singrakhia, “Painful osteoporotic vertebral fracture. Pathogenesis, evaluation, and roles of vertebroplasty and kyphoplasty in its management,” The Journal of Bone and Joint Surgery—Series A, vol. 85, no. 10, pp. 2010–2022, 2003. View at Google Scholar · View at Scopus
- M. Cree, C. L. Soskolne, E. Belseck et al., “Mortality and institutionalization following hip fracture,” Journal of the American Geriatrics Society, vol. 48, no. 3, pp. 283–288, 2000. View at Google Scholar · View at Scopus
- K. Izumotani, S. Hagiwara, T. Izumotani, T. Miki, H. Morii, and Y. Nishizawa, “Risk factors for osteoporosis in men,” Journal of Bone and Mineral Metabolism, vol. 21, no. 2, pp. 86–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. Center, H. Beange, and A. McElduff, “People with mental retardation have an increased prevalence of osteoporosis: a population study,” American Journal of Mental Retardation, vol. 103, no. 1, pp. 19–28, 1998. View at Publisher · View at Google Scholar
- R. G. Zylstra, L. L. Porter, J. L. Shapiro, and C. D. Prater, “Prevalence of osteoporosis in community-dwelling individuals with intellectual and/or developmental disabilities,” Journal of the American Medical Directors Association, vol. 9, no. 2, pp. 109–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. S. Lohiya, L. Tan-Figueroa, and A. Iannucci, “Identification of low bone mass in a developmental center: finger bone mineral density measurement in 562 residents,” Journal of the American Medical Directors Association, vol. 5, no. 6, pp. 371–376, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. V. Tyler Jr., C. W. Snyder, and S. Zyzanski, “Screening for osteoporosis in community-dwelling adults with mental retardation,” Mental Retardation, vol. 38, no. 4, pp. 316–321, 2000. View at Google Scholar · View at Scopus
- J. S. Jaffe and A. M. Timell, “Prevalence of low bone density in institutionalized men with developmental disabilities,” Journal of Clinical Densitometry, vol. 6, no. 2, pp. 143–147, 2003. View at Publisher · View at Google Scholar · View at Scopus
- T. J. Aspray, R. M. Francis, A. Thompson, S. J. Quilliam, D. J. Rawlings, and S. P. Tyrer, “Comparison of ultrasound measurements at the heel between adults with mental retardation and control subjects,” Bone, vol. 22, no. 6, pp. 665–668, 1998. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Jaffe, A. M. Timell, R. Elolia, and S. S. Thatcher, “Risk factors for low bone mineral density in individuals residing in a facility for the people with intellectual disability,” Journal of Intellectual Disability Research, vol. 49, no. 6, pp. 457–462, 2005. View at Publisher · View at Google Scholar · View at Scopus
- N. R. Glick, M. H. Fischer, D. M. Heisey, G. E. Leverson, and D. C. Mann, “Epidemiology of fractures in people with severe and profound developmental disabilities,” Osteoporosis International, vol. 16, no. 4, pp. 389–396, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. Fisher and P. Kettl, “Aging with mental retardation: increasing population of older adults with MR require health interventions and prevention strategies,” Geriatrics, vol. 60, no. 4, pp. 26–29, 2005. View at Google Scholar · View at Scopus
- S. Schrager, “Osteoporosis in women with disabilities,” Journal of Women's Health, vol. 13, no. 4, pp. 431–437, 2004. View at Google Scholar · View at Scopus
- G. S. Lohiya, F. M. Crinella, L. Tan-Figueroa, S. Caires, and S. Lohiya, “Fracture epidemiology and control in a developmental center,” Western Journal of Medicine, vol. 170, no. 4, pp. 203–209, 1999. View at Google Scholar · View at Scopus
- T. N. Tannenbaum, L. Lipworth, and S. Baker, “Risk of fractures in an intermediate care facility for persons with mental retardation,” American Journal on Mental Retardation, vol. 93, no. 4, pp. 444–451, 1989. View at Google Scholar · View at Scopus
- W. C. Graafmans, M. E. Ooms, H. M. A. Hofstee, P. D. Bezemer, L. M. Bouter, and P. Lips, “Falls in the elderly: a prospective study of risk factors and risk profiles,” American Journal of Epidemiology, vol. 143, no. 11, pp. 1129–1136, 1996. View at Google Scholar · View at Scopus
- T. D. Peabody and P. J. Stasikelis, “Fractures in adults at an institution for the developmentally disabled,” Clinical Orthopaedics and Related Research, no. 366, pp. 217–220, 1999. View at Google Scholar · View at Scopus
- K. M. Ryder, J. Williams, C. Womack et al., “Appendicular fractures: a significant problem among institutionalized adults with developmental disabilities,” American Journal of Mental Retardation, vol. 108, no. 5, pp. 340–346, 2003. View at Publisher · View at Google Scholar
- J. P. Hough, R. N. Boyd, and J. L. Keating, “Systematic review of interventions for low bone mineral density in children with cerebral palsy,” Pediatrics, vol. 125, no. 3, pp. e670–e678, 2010. View at Publisher · View at Google Scholar · View at Scopus
- O. Ali, M. Shim, E. Fowler et al., “Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 3, pp. 932–937, 2007. View at Publisher · View at Google Scholar · View at Scopus
- M. L. Reyes, M. Hernández, L. J. Holmgren, E. Sanhueza, and R. G. Escobar, “High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children,” Journal of Bone and Mineral Research, vol. 26, no. 8, pp. 1759–1766, 2011. View at Publisher · View at Google Scholar · View at Scopus
- P. Kilpinen-Loisa, T. Paasio, M. Soiva et al., “Low bone mass in patients with motor disability: prevalence and risk factors in 59 Finnish children,” Developmental Medicine and Child Neurology, vol. 52, no. 3, pp. 276–282, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. Kilpinen-Loisa, M. Arvio, V. Ilvesmäki, and O. Mäkitie, “Vitamin D status and optimal supplementation in institutionalized adults with intellectual disability,” Journal of Intellectual Disability Research, vol. 53, no. 12, pp. 1014–1023, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. M. Ryder, S. B. Tanner, L. Carbone et al., “Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosis,” Journal of Bone and Mineral Metabolism, vol. 28, no. 2, pp. 233–239, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. J. Accardo and and H. Paul, Eds., Capute and Accardo's Neurodevelopmental Disabilities in Infancy and Childhood, Brookes Publishing, Baltimore, Md, USA, 3rd edition, 2008.
- C. H. Kao, C. C. Chen, S. J. Wang, and S. H. Yeh, “Bone mineral density in children with Down's syndrome detected by dual photon absorptiometry,” Nuclear Medicine Communications, vol. 13, no. 10, pp. 773–775, 1992. View at Google Scholar · View at Scopus
- A. González-Agüero, G. Vicente-Rodríguez, L. A. Moreno, and J. A. Casajús, “Bone mass in male and female children and adolescents with Down syndrome,” Osteoporosis International, vol. 22, no. 7, pp. 2151–2157, 2011. View at Publisher · View at Google Scholar · View at Scopus
- F. Baptista, A. Varela, and L. B. Sardinha, “Bone mineral mass in males and females with and without Down syndrome,” Osteoporosis International, vol. 16, no. 4, pp. 380–388, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. Guijarro, C. Valero, B. Paule, J. Gonzalez-Macias, and J. A. Riancho, “Bone mass in young adults with Down syndrome,” Journal of Intellectual Disability Research, vol. 52, no. 3, pp. 182–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
- N. Angelopoulou, C. Matziari, V. Tsimaras, A. Sakadamis, V. Souftas, and K. Mandroukas, “Bone mineral density and muscle strength in young men with mental retardation (with and without Down syndrome),” Calcified Tissue International, vol. 66, no. 3, pp. 176–180, 2000. View at Publisher · View at Google Scholar · View at Scopus
- Z. Tümer, A. M. Henriksen, I. Bache et al., “Eponymous Jacobsen syndrome: mapping the breakpoints of the original family suggests an association between the distal 1.1 Mb of chromosome 21 and osteoporosis in Down syndrome,” American Journal of Medical Genetics, vol. 135, no. 3, pp. 339–341, 2005. View at Publisher · View at Google Scholar · View at Scopus
- B. K. Shapiro, “Cerebral palsy: a reconceptualization of the spectrum,” The Journal of Pediatrics, vol. 145, no. 2, pp. S3–S7, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. Mergler, H. M. Evenhuis, A. M. Boot et al., “Epidemiology of low bone mineral density and fractures in children with severe cerebral palsy: a systematic review,” Developmental Medicine and Child Neurology, vol. 51, no. 10, pp. 773–778, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Stevenson, M. Conaway, J. W. Barrington, S. L. Cuthill, G. Worley, and R. C. Henderson, “Fracture rate in children with cerebral palsy,” Pediatric Rehabilitation, no. 4, pp. 396–403, 2006. View at Publisher · View at Google Scholar · View at Scopus
- R. C. Henderson, R. K. Lark, M. J. Gurka et al., “Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy,” Pediatrics, vol. 110, no. 1, article e5, pp. 1–10, 2002. View at Google Scholar · View at Scopus
- R. C. Henderson, “Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia,” Developmental Medicine and Child Neurology, vol. 39, no. 4, pp. 224–227, 1997. View at Google Scholar · View at Scopus
- R. C. Henderson, J. A. Kairalla, J. W. Barrington, A. Abbas, and R. D. Stevenson, “Longitudinal changes in bone density in children and adolescents with moderate to severe cerebral palsy,” The Journal of Pediatrics, vol. 146, no. 6, pp. 769–775, 2005. View at Publisher · View at Google Scholar · View at Scopus
- C. Hartman, R. Brik, A. Tamir, J. Merrick, and R. Shamir, “Bone quantitative ultrasound and nutritional status in severely handicapped institutionalized children and adolescents,” Clinical Nutrition, vol. 23, no. 1, pp. 89–98, 2004. View at Publisher · View at Google Scholar · View at Scopus
- W. King, R. Levin, R. Schmidt, A. Oestreich, and J. E. Heubi, “Prevalence of reduced bone mass in children and adults with spastic quadriplegia,” Developmental Medicine and Child Neurology, vol. 45, no. 1, pp. 12–16, 2003. View at Google Scholar · View at Scopus
- A. Cohen, M. Lancman, H. Mogul, S. Marks, and K. Smith, “Strategies to protect bone mass in the older patient with epilepsy,” Geriatrics, vol. 52, no. 8, pp. 70–81, 1997. View at Google Scholar · View at Scopus
- C. L. Chen, J. Y. Ke, C. J. Wang, K. P. Wu, C. Y. Wu, and A. M. K. Wong, “Factors associated with bone density in different skeletal regions in children with cerebral palsy of various motor severities,” Developmental Medicine and Child Neurology, vol. 53, no. 2, pp. 131–136, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. L. Chen, K. C. Lin, C. Y. Wu, J. Y. Ke, C. J. Wang, and C. Y. Chen, “Relationships of muscle strength and bone mineral density in ambulatory children with cerebral palsy,” Osteoporosis International, vol. 23, no. 2, pp. 715–721, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. Nakano, K. Aovagi, S. Ohgi, and T. Akiyama, “Factors influencing metacarpal bone mineral density in adults with cerebral palsy,” Journal of Bone and Mineral Metabolism, vol. 21, no. 6, pp. 409–414, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. D. Stevenson and M. Conaway, “Growth assessment of children with cerebral palsy: the clinician's conundrum,” Developmental Medicine and Child Neurology, vol. 49, no. 3, article 164, 2007. View at Publisher · View at Google Scholar · View at Scopus
- E. Heervä, M. H. Alanne, S. Peltonen et al., “Osteoclasts in neurofibromatosis type 1 display enhanced resorption capacity, aberrant morphology, and resistance to serum deprivation,” Bone, vol. 47, no. 3, pp. 583–590, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. H. Ralston and A. G. Uitterlinden, “Genetics of osteoporosis,” Endocrine Reviews, vol. 31, no. 5, pp. 629–662, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. D. K. Lee, “Endocrine and metabolic aspects of Prader-Willi syndrome,” in Management of Prader-Willi Syndrome, L. R. Greenswag and R. C. Alexander, Eds., pp. 32–57, Springer, New York, NY, USA, 1995. View at Google Scholar