TY - JOUR
A2 - Posner, Barry
AU - Figueiro, Mariana G.
AU - Plitnick, Barbara
AU - Rea, Mark S.
PY - 2012
DA - 2012/09/04
TI - Light Modulates Leptin and Ghrelin in Sleep-Restricted Adults
SP - 530726
VL - 2012
AB - Acute and chronic sleep restrictions cause a reduction in leptin and an increase in ghrelin, both of which are associated with hunger. Given that light/dark patterns are closely tied to sleep/wake patterns, we compared, in a within-subjects study, the impact of morning light exposures (60 lux of 633-nm [red], 532-nm [green], or 475-nm [blue] lights) to dim light exposures on leptin and ghrelin concentrations after subjects experienced 5 consecutive days of both an 8-hour (baseline) and a 5-hour sleep-restricted schedule. In morning dim light, 5-hour sleep restriction significantly reduced leptin concentrations compared to the baseline, 8-hour sleep/dim-light condition (t1,32 = 2.9; P=0.007). Compared to the 5-hour sleep/dim-light condition, the red, green, and blue morning light exposures significantly increased leptin concentrations (t1,32 = 5.7; P<0.0001, t1,32 = 3.6; P=0.001, and t1,32 = 3.0; P=0.005, resp.). Morning red light and green light exposures significantly decreased ghrelin concentrations (t1,32 = 3.3; P<0.003 and t1,32 = 2.2; P=0.04, resp.), but morning blue light exposures did not. This study is the first to demonstrate that morning light can modulate leptin and ghrelin concentrations, which could have an impact on reducing hunger that accompanies sleep deprivation.
SN - 1687-8337
UR - https://doi.org/10.1155/2012/530726
DO - 10.1155/2012/530726
JF - International Journal of Endocrinology
PB - Hindawi Publishing Corporation
KW -
ER -