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International Journal of Endocrinology
Volume 2012 (2012), Article ID 598180, 5 pages
Research Article

Bisphenol A and Metabolic Syndrome: Results from NHANES

1Department of Epidemiology, West Virginia University School of Public Health, P.O. Box 9190, Morgantown, WV 26506-9190, USA
2Department of Pharmaceutical Systems and Policy, West Virginia University School of Pharmacy, Morgantown, WV 26506, USA

Received 21 August 2012; Accepted 29 October 2012

Academic Editor: Mario Maggi

Copyright © 2012 Srinivas Teppala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Bisphenol A (BPA) is detected in the urine of 95% of US adults. Recent evidence from population-based studies suggests that BPA is associated with individual components for metabolic syndrome (MetS). However, no previous study has examined the direct association between BPA and MetS. Methods. We examined 2,104 participants from the National Health and Nutrition Examination Survey 2003–2008. The main outcome was the presence of MetS ( ). Results. Increasing levels of urinary BPA were positively associated with MetS, independent of confounders such as age, gender, race/ethnicity, smoking, alcohol intake, physical activity, and urinary creatinine. Compared to tertile 1 (referent), the multivariable adjusted odds ratio (95% confidence interval) of MetS in tertile 3 was 1.51 (1.07–2.12); -trend was 0.02. Conclusions. Urinary BPA levels are positively associated with MetS, in a representative sample of US adults and independent of traditional risk factors for MetS. Future, prospective studies are needed to confirm our findings.