Compromised Rat Testicular Antioxidant Defence System by Hypothyroidism before Puberty

Table 5

Effect of neonatal PTU treatment on total, oxidized, reduced glutathione contents (nmol thiols/g tissue) of testes of rats. Data are expressed as mean ± S.D. of 5 observations and subjected to unpaired Student’s t-test. Statistical significance was accepted at 𝑃<0.05. Control and hypothyroid groups were found to differ significantly at 𝑃<0.05 as represented by superscripts of different letters. Group-I (Control): 30 day old control rats; Group-II (Hypothyroid): 30-day-old rats with PTU treatment from day 1 postpartum to day 30 postpartum; T-GSH-eq: total GSH equivalent; GSH: reduced glutathione, GSSG: oxidized glutathione.

		Group-I (control)	Group-II (hypothyroid)
MF	T-GSH-eq (nmol thiols/g tissue)	108.89 ± 8.53^a	54.45 ± 4.26^b
	GSSG (nmol thiols/g tissue)	18.59 ± 1.53^a	15.49 ± 1.28^b
	GSH (nmol thiols/g tissue)	71.72 ± 5.48^a	23.47 ± 1.73^b
	GSH : GSSG (nmol thiols/g tissue)	3.86 ± 0.04^a	1.52 ± 0.02^b
PMF	T-GSH-eq (nmol thiols/g tissue)	1227.23 ± 96.12^a	1133.54 ± 80.64^a
	GSSG (nmol thiols/g tissue)	116.98 ± 9.81^a	89.43 ± 8.21^b
	GSH (nmol thiols/g tissue)	992.74 ± 76.71^a	954.40 ± 79.96^a
	GSH : GSSG (nmol thiols/g tissue)	8.48 ± 0.07^a	10.75 ± 1.40^b