Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Figure 1
Caloric restriction and wheel running alter body weight gain and food intake in C57Bl/6 and leptin receptor-deficient mice. (a) C57Bl/6 mice maintained on 40% caloric restriction (CR) gain weight more slowly than wild-type mice on the ad libitum (AL) diet. db/db mice maintained on CR from one month of age did not significantly gain weight over the subsequent twelve weeks of the experiment, and voluntary wheel running decelerates body weight gain in db/db mice. (b) Running transiently suppresses food intake in db/db mice. Data were analyzed with 2 × 3 repeated measures ANOVA with Tukey’s post hoc and significance set at . Error bars represent SEM.
