Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Figure 5
CR influences hypothalamic gene expression and pathway recruitment in wild-type mice. (a) Z-ratios for genes that were up- or down-regulated following CR in wild-type mice. Otof, otoferlin; Ylpm1, YLP motif containing 1; Wipf1, WAS/WASL interacting protein family, member 1; Igf1, insulin-like growth factor 1; Pltp, phospholipid transfer protein; Cln6, ceroid-lipofuscinosis, neuronal 6. (b) Pathway analysis of genes responsive to CR in wild-type mice. Abbreviations: Zic1, zinc finger protein of the cerebellum 1; E2f1, E2F transcription factor 1; Nde1, nuclear distribution gene E homolog 1; Adcyap1r1, adenylate cyclase activating polypeptide 1 receptor 1; Ntrk3, neurotrophic tyrosine kinase, receptor, type 3; Id2, inhibitor of DNA binding 2; Xrcc6, X-ray repair in Chinese hamster cells 6; Dicer1, Dicer1 homolog. (c) PCR validation of changes in gene expression following CR in wild-type mice.
