Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Figure 9
Physiological background differentially modulates the effects of exercise and caloric restriction upon hypothalamic transcriptomes. (a) Venn diagram illustrates the number of significantly regulated genes (up- and downregulated) affected by exercise (Run) in WT (red) or db/db (blue) animals. The associated histogram indicates the significantly regulated genes common to the effects of exercise in both genetic backgrounds (WT and db/db). The yellow area indicates the genes whose direction of regulation was conserved in both genetic backgrounds while the grey area shows the genes that showed reversal of their exercise-mediated expression profile. (b) Venn diagram and associated histogram depict similar data to (a) but for the implementation of CR to the WT (blue) or db/db (red) mice. (c) Significantly regulated pathways associated with the conserved CR-induced transcriptional activity in both WT and db/db mice.
