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International Journal of Endocrinology
Volume 2012 (2012), Article ID 810926, 6 pages
Clinical Study

Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study

1Winchester Medical Center, Heart and Vascular Center, Winchester, VA 22601, USA
2Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USA

Received 28 March 2012; Revised 16 August 2012; Accepted 30 August 2012

Academic Editor: Dariush Elahi

Copyright © 2012 Marcia L. Brackbill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagliptin or placebo after surgery for 4 days. The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery. Results. Sixty-two patients participated. Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of  mg/dL and  mg/dL for the test and the control group, respectively ( ). Conclusions. Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting.