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International Journal of Endocrinology
Volume 2012, Article ID 821579, 7 pages
Review Article

Gamma Knife Radiosurgery for Acromegaly

1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA
2California Center for Pituitary Disorders, University of California, San Francisco, San Francisco, CA 94143-0350, USA

Received 10 September 2011; Revised 18 November 2011; Accepted 23 November 2011

Academic Editor: Anil K. Agarwal

Copyright © 2012 John D. Rolston and Lewis S. Blevins Jr. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acromegaly is debilitating disease occasionally refractory to surgical and medical treatment. Stereotactic radiosurgery, and in particular Gamma Knife surgery (GKS), has proven to be an effective noninvasive adjunct to traditional treatments, leading to disease remission in a substantial proportion of patients. Such remission holds the promise of eliminating the need for expensive medications, along with side effects, as well as sparing patients the damaging sequelae of uncontrolled acromegaly. Numerous studies of radiosurgical treatments for acromegaly have been carried out. These illustrate an overall remission rate over 40%. Morbidity from radiosurgery is infrequent but can include cranial nerve palsies and hypopituitarism. Overall, stereotactic radiosurgery is a promising therapy for patients with acromegaly and deserves further study to refine its role in the treatment of affected patients.