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International Journal of Endocrinology
Volume 2012 (2012), Article ID 862892, 5 pages
Review Article

Long-Term Followup of Adolescent and Young Adult Females with Hypergonadotropic Hypogonadism

2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 115 26 Athens, Greece

Received 1 September 2011; Accepted 18 October 2011

Academic Editor: Gil Guerra-Junior

Copyright © 2012 Tsimaris Pantelis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The condition characterized by elevated gonadotrophins (gonadotropins elevated into the menopausal range), low sex steroids, and menstrual disorders was previously termed Premature Ovarian Failure (POF). However, over the last two years an effort has been made by many authors to have the term Primary Ovarian Insufficiency (POI) exclusively applied. Irrespective of the term, the condition concerns adolescent and young adult women under 40 years who experience cessation of menstruation for more than 3 cycles (whereas these women in the past had a rhythmic menstrual cycle) or amenorrhea for 4–6 months against the background of a previously disturbed menstrual cycle. Determining the cause of POI is difficult, and it is even harder to deal with problems arising from the paucity of estrogen as well as to draw up the plan for long-term monitoring of these patients. This paper presents long-term therapeutic management strategies concerning emotional health, hormone replacement therapy, maintenance of bone health, family planning, other associated disorders as well as possible research options for the future.