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International Journal of Endocrinology
Volume 2012, Article ID 907818, 7 pages
http://dx.doi.org/10.1155/2012/907818
Research Article

Estimation of Insulin Resistance in Mexican Adults by the [13C]Glucose Breath Test Corrected for Endogenous Total CO2 Production

1Nutrition Division, Centro de Investigación en Alimentacion y Desarrollo, A.C., Mexico
2Department of Medicine and Health Sciences, University of Sonora, Hermosillo, Mexico
3Energy Metabolism and Body Composition Laboratory, Department of Chemical and Biological Sciences, University of Sonora, Hermosillo, Mexico

Received 22 March 2012; Accepted 16 May 2012

Academic Editor: Mario Maggi

Copyright © 2012 Erika Ibarra-Pastrana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the efficacy of the [13C]glucose breath test for measuring insulin resistance in Mexican adults with different glycemic states. Research Design and Methods. Fifty-eight adults underwent a [13C]glucose breath test with simultaneous measurement of total CO2 production by indirect calorimetry, at baseline and 90 minutes after the ingestion of 15 g of dextrose and 25 mg of [13C]glucose. HOMA was used as a marker of insulin resistance. Results. We found an inverse correlation between HOMA and the breath test δ13CO2 (‰), ( ). After adjusting for total CO2 production, correlations between HOMA and fasting glucose were less strong but remained significant. An ROC curve was constructed using δ13CO2 (‰) and HOMA values; the cut-off point was 9.99‰ δ13CO2, corresponding to a sensitivity of 80.0 (95% CI: 51.9, 95.7) and a specificity of 67.4 (95% CI: 51.5, 80.9). Conclusions. The [13C]glucose breath test is a simple noninvasive procedure but was not sufficiently robust for an accurate diagnosis of insulin resistance. Our findings suggest that the test might be helpful in identifying individuals who are not IR, which in turn may contribute to improved diabetes prevention.