Arginine 16 Glycine Polymorphism in β2-Adrenergic Receptor Gene Is Associated with Obesity, Hyperlipidemia, Hyperleptinemia, and Insulin Resistance in Saudis
Table 4
Association of β2AR genotype in codon 16 with phenotypic characteristics of the subjects.
Variables
Arg∖Arg (n = 191) mean ± SE
Arg∖Gly (n = 68) mean ± SE
Gly∖Gly (n = 70) mean ± SE
P value
BMI (kg/m2)
27.15 ± 0.51
28.82 ± 0.85
31.88 ± 0.91
0.0001
Waist (cm)
85.32 ± 1.32
89.24 ± 2.14
95.89 ± 2.28
0.0001
Hip (cm)
105.48 ± 1.05
108.32 ± 1.71
113.81 ± 1.97
0.0001
W/H ratio
0.80 ± 0.006
0.82 ± 0.01
0.84 ± 0.01
0.025
Cholesterol (mmol/L)
3.90 ± 0.06
4.03 ± .09
4.32 ± .11
0.002
Triglyceride (mmol/L)
0.99 ± 0.03
1.09 ± 0.05
1.21 ± 0.06
0.003
HDL-cholesterol (mmol/L)
1.20 ± .02
1.19 ± .05
1.11 ± .04
0.141
LDL-cholesterol (mmol/L)
2.013 ± 06
2.11 ± .09
2.34 ± .088
0.012
Leptin (ng/mL)
19.80 ± 1.11
24.96 ± 2.59
29.56 ± 2.64
0.0001
Fasting insulin (pmol/L)
76.57 ± 2.74
86.62 ± 4.61
92.21 ± 4.93
0.09
Fasting glucose (mmol/L)
4.91 ± .04
4.92 ± 06
5.03 ± 05
0.24
HOMA-IR
2.40 ± 0.09
2.75 ± 0.15
3.00 ± 0.17
0.003
Abbreviations—BMI: body mass index; W/H: waist hip ratio.
