Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus
Table 3
Correlation between serum OPG, sRANKL, sonographic findings, and demographic, anthropometric, and biochemical parameters in children and adolescents with type 1 diabetes mellitus.
OPG (pmol/L)
sRANKL (pmol/L)
RcIMT (mm)
LcIMT (mm)
CcIMT (mm)
Age (years)
−0.271*
−0.203
0.233
0.483**
0.380*
BMI (kg/m2)
−0.331**
−0.107
0.294
0.489**
0.418*
Diabetes duration (years)
−0.136
0.040
0.236
0.242
0.176
HbA1c (%)
0.015
0.054
−0.309
−0.134
−0.241
Glucose (mg/dL)
0.175
0.043
0.213
0.112
0.178
Urea (mg/dL)
0.004
0.058
−0.246
−0.064
−0.173
Creatinine (mg/dL)
−0.200
−0.182
0.128
−0.355
0.255
eGFR (mL/min)
−0.039
−0.033
0.109
0.090
0.186
CRP (mg/dL)
0.077
−0.007
−0.265
−0.352
−0.331
Tchol (mg/dL)
0.214
−0.012
0.003
−0.197
−0.099
TG (mg/dL)
0.048
0.083
0.247
0.201
0.244
HDL-C (mg/dL)
0.071
−0.045
0.061
0.006
0.038
LDL-C (mg/dL)
0.197
−0.025
−0.079
−0.267
−0.182
ApoA1 (mg/dL)
0.157
−0.096
0.073
0.143
0.115
ApoB (mg/dL)
0.235
−0.033
−0.047
−0.296
−0.179
WBC (cells/μL)
−0.081
0.216
−0.009
−0.108
−0.060
PLT (cells/μL)
0.117
0.127
0.107
−0.165
−0.024
OPG (pmol/L)
—
0.166
−0.096
−0.269
−0.193
sRANKL (pmol/L)
—
—
−0.221
−0.290
−0.231
P value < 0.05 and **P value < 0.01. BMI: body mass index; eGFR: Estimated Glomerular Filtration Rate; Tchol: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; WBC: white blood cells; PLT: platelets; OPG: osteoprotegerin; sRANKL: serum receptor activator of nuclear factor-κB ligand; (R/L/C)cIMT: (right/left/combined) carotid intima-media thickness.
