International Journal of Endocrinology / 2013 / Article / Tab 4

Clinical Study

Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Table 4

Stepwise linear regression with OPG and cIMT as dependent variables, adjusting for anthropometric and biochemical variables and diabetes status.

Dependent variableIndependent variableModel Standardized β (mean effect on dependent variable per unit increase of independent variable)P value

T1DM + controls* ( )

OPG (pmol/L)0.1100.003
BMI−0.3350.003
Presence of T1DM0.1400.197
Male
(versus female)
0.0790.477
Age−0.0990.483

cIMT (mm)0.1750.027
BMI0.4180.027
Presence of T1DM−0.1960.282
Male
(versus female)
−0.1920.319
Age0.1620.544
OPG−0.0120.953

T1DM** ( )

OPG (pmol/L)0.1270.008
BMI−0.3560.008
Age−0.0760.645
Male
(versus female)
0.1160.390
Years of diabetes−0.0330.807
HbA1c0.0680.605

cIMT (mm)0.3650.013
BMI0.6040.013
Age−0.3730.321
Male
(versus female)
−0.1270.615
Years of diabetes0.2380.281
HbA1c−0.1690.450
OPG0.1050.718

DM: diabetes mellitus; ΒMΙ: body mass index; OPG: osteoprotegerin; cIMT: (combined) carotid intima-media thickness.
*Age, gender, and presence of type 1 diabetes mellitus a priori entered in the model; BMI entered through the stepwise procedure; OPG a priori entered when examining cIMT.
**Age, gender, and years of diabetes and HbA1c a priori entered in the model; BMI entered through the stepwise procedure; OPG a priori entered when examining cIMT.