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International Journal of Endocrinology
Volume 2013, Article ID 128907, 6 pages
http://dx.doi.org/10.1155/2013/128907
Review Article

Serum AMH in Physiology and Pathology of Male Gonads

Pediatric Surgery Department, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, Poland

Received 13 April 2013; Accepted 23 September 2013

Academic Editor: Volker Ziller

Copyright © 2013 Ewa Matuszczak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Lee and P. K. Donahoe, “Mullerian inhibiting substance: a gonadal hormone with multiple functions,” Endocrine Reviews, vol. 14, no. 2, pp. 152–164, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. R. A. Rey and R. P. Grinspon, “Normal male sexual differentiation and aetiology of disorders of sex development,” Best Practice and Research Clinical Endocrinology and Metabolism, vol. 25, no. 2, pp. 221–238, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Rey, C. Lukas-Croisier, C. Lasala, and P. Bedecarrás, “AMH/MIS: what we know already about the gene, the protein and its regulation,” Molecular and Cellular Endocrinology, vol. 211, no. 1-2, pp. 21–31, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. O. Taguchi, G. R. Cunha, W. D. Lawrence, and S. J. Robboy, “Timing and irreversibility of Mullerian duct inhibition in the embryonic reproductive tract of the human male,” Developmental Biology, vol. 106, no. 2, pp. 394–398, 1984. View at Google Scholar · View at Scopus
  5. I. Bergadá, C. Milani, P. Bedecarrás et al., “Time course of the serum gonadotropin surge, inhibins, and anti-Müllerian hormone in normal newborn males during the first month of life,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 10, pp. 4092–4098, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Lukas-Croisier, C. Lasala, J. Nicaud et al., “Follicle-stimulating hormone increases testicular anti-Müllerian hormone (AMH) production through Sertoli cell proliferation and a nonclassical cyclic adenosine 5′-monophosphate-mediated activation of the AMH gene,” Molecular Endocrinology, vol. 17, no. 4, pp. 550–561, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Al-Attar, K. Noël, M. Dutertre et al., “Hormonal and cellular regulation of Sertoli cell anti-Mullerian hormone production in the postnatal mouse,” The Journal of Clinical Investigation, vol. 100, no. 6, pp. 1335–1343, 1997. View at Google Scholar · View at Scopus
  8. M. M. Grumbach, “Commentary: a window of opportunity: the diagnosis of gonadotropin deficiency in the male infant,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 5, pp. 3122–3127, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. M. M. Lee, M. Misra, P. K. Donahoe, and D. T. MacLaughlin, “MIS/AMH in the assessment of cryptorchidism and intersex conditions,” Molecular and Cellular Endocrinology, vol. 211, no. 1-2, pp. 91–98, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Hero, J. Tommiska, K. Vaaralahti et al., “Circulating antimüllerian hormone levels in boys decline during early puberty and correlate with inhibin B,” Fertility and Sterility, vol. 97, no. 5, pp. 1242–1247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. K. A. L. Tan, K. De Gendt, N. Atanassova et al., “The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or sertoli cell-selective ablation of the androgen receptor,” Endocrinology, vol. 146, no. 6, pp. 2674–2683, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Boukari, G. Meduri, S. Brailly-Tabard et al., “Lack of androgen receptor expression in sertoli cells accounts for the absence of anti-Mullerian hormone repression during early human testis development,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 5, pp. 1818–1825, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Aksglaede, K. Sørensen, M. Boas et al., “Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 12, pp. 5357–5364, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. P. Grinspon, P. Bedecarrás, M. G. Ballerini et al., “Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21,” International Journal of Andrology, vol. 34, no. 5, pp. e487–e498, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Young, P. Chanson, S. Salenave et al., “Testicular anti-Müllerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 2, pp. 724–728, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Eldar-Geva, G. Liberty, B. Chertin et al., “Relationships between FSH, inhibin B, anti-Mullerian hormone, and testosterone during long-term treatment with the GnRH-agonist histrelin in patients with prostate cancer,” European Journal of Endocrinology, vol. 162, no. 1, pp. 177–181, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Fujisawa, T. Yamazaki, H. Fujioka, and A. Takenaka, “Differential regulation of inhibin subunits by germ cells in human testes,” Archives of Andrology, vol. 50, no. 5, pp. 339–345, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Nistal, A. Abaurrea, and R. Paniagua, “Morphological and histometric study on the human Sertoli cell from birth to the onset of puberty,” Journal of Anatomy, vol. 134, no. 2, pp. 351–363, 1982. View at Google Scholar · View at Scopus
  19. H. E. Chemes, “Infancy is not a quiescent period of testicular development,” International Journal of Andrology, vol. 24, no. 1, pp. 2–7, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. N. G. Wreford, T. R. Kumar, M. M. Matzuk, and D. M. de Kretser, “Analysis of the testicular phenotype of the follicle-stimulating hormone β-subunit knockout and the activin type II receptor knockout mice by stereological analysis,” Endocrinology, vol. 142, no. 7, pp. 2916–2920, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Pitteloud, F. J. Hayes, P. A. Boepple et al., “The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 1, pp. 152–160, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Teixeira, S. Maheswaran, and P. K. Donahoe, “Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications,” Endocrine Reviews, vol. 22, no. 5, pp. 657–674, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. A. A. Sinisi, D. Esposito, L. Maione et al., “Seminal anti-Müllerian hormone level is a marker of spermatogenic response during long-term gonadotropin therapy in male hypogonadotropic hypogonadism,” Human Reproduction, vol. 23, no. 5, pp. 1029–1034, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. M. Hutson, “Testicular feminization: a model for testicular descent in mice and men,” Journal of Pediatric Surgery, vol. 21, no. 3, pp. 195–198, 1986. View at Google Scholar · View at Scopus
  25. M. Fujisawa, T. Yamasaki, H. Okada, and S. Kamidono, “The significance of anti-Müllerian hormone concentration in seminal plasma for spermatogenesis,” Human Reproduction, vol. 17, no. 4, pp. 968–970, 2002. View at Google Scholar · View at Scopus
  26. N. Josso, R. Rey, and J. Y. Picard, “Testicular anti-Mullerian hormone: clinical applications in DSD,” Seminars in Reproductive Medicine, vol. 30, no. 5, pp. 364–373, 2012. View at Google Scholar
  27. N. Josso, C. Belville, N. di Clemente, and J.-Y. Picard, “AMH and AMH receptor defects in persistent Müllerian duct syndrome,” Human Reproduction Update, vol. 11, no. 4, pp. 351–356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Kubini, M. Zachmann, N. Albers et al., “Basal inhibin B and the testosterone response to human chorionic gonadotropin correlate in prepubertal boys,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 1, pp. 134–138, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. S. T. Thompson, M. A. Grillis, L. H. Wolkoff, and W. E. Katzin, “Transverse testicular ectopia in a man with persistent mullerian duct syndrome,” Archives of Pathology and Laboratory Medicine, vol. 118, no. 7, pp. 752–755, 1994. View at Google Scholar · View at Scopus
  30. R. A. Rey, C. Belville, C. Nihoul-Fekete et al., “Evaluation of gonadal function in 107 intersex patients by means of serum antiMüllerian hormone measurement,” The Journal of Clinical Endocrinology & Metabolism, vol. 84, pp. 627–631, 1999. View at Google Scholar
  31. R. Werner, H. Grötsch, and O. Hiort, “46,XY disorders of sex development—the undermasculinised male with disorders of androgen action,” Best Practice and Research Clinical Endocrinology and Metabolism, vol. 24, no. 2, pp. 263–277, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Belville, J.-D. Maréchal, S. Pennetier et al., “Natural mutations of the anti-Müllerian hormone type II receptor found in persistent Müllerian duct syndrome affect ligand binding, signal transduction and cellular transport,” Human Molecular Genetics, vol. 18, no. 16, pp. 3002–3013, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. R. A. Rey, R. P. Grinspon, S. Gottlieb et al., “Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach,” Andrology, vol. 1, pp. 3–16, 2013. View at Google Scholar
  34. T. Raivio, A. M. Wikström, and L. Dunkel, “Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome,” European Journal of Endocrinology, vol. 156, no. 1, pp. 105–111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Coutant, E. Biette-Demeneix, C. Bouvattier et al., “Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 12, pp. 5225–5232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Bougnères, M. François, L. Pantalone et al., “Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 6, pp. 2202–2205, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. M. M. Lee, P. K. Donahoe, B. L. Silverman et al., “Measurements of serum Müllerian inhibiting substance in the evaluation of children with nonpalpable gonads,” The New England Journal of Medicine, vol. 336, pp. 1480–1486, 1997. View at Google Scholar
  38. M. L. Gustafson, M. M. Lee, R. E. Scully et al., “Mullerian inhibiting substance as a marker for ovarian sex-cord tumor,” The New England Journal of Medicine, vol. 326, no. 7, pp. 466–471, 1992. View at Google Scholar · View at Scopus
  39. R. A. Rey, C. Lhomme, I. Marcillac et al., “AntiMüllerian hormone as a serum marker of granulosa cell tumors of the ovary: comparative study with serum α-inhibin and estradiol,” American Journal of Obstetrics and Gynecology, vol. 174, no. 3, pp. 958–965, 1996. View at Publisher · View at Google Scholar · View at Scopus
  40. J. M. Hutson, S. Hasthorpe, and C. F. Heyns, “Anatomical and functional aspects of testicular descent and cryptorchidism,” Endocrine Reviews, vol. 18, no. 2, pp. 259–280, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. J. M. Hutson and S. Hasthorpe, “Testicular descent and cryptorchidism: the state of the art in 2004,” Journal of Pediatric Surgery, vol. 40, no. 2, pp. 297–302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. I. M. Adham and A. I. Agoulnik, “Insulin-like 3 signalling in testicular descent,” International Journal of Andrology, vol. 27, no. 5, pp. 257–265, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Nef and L. F. Parada, “Cryptorchidism in mice mutant for Insl3,” Nature Genetics, vol. 22, no. 3, pp. 295–299, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Zimmermann, G. Steding, J. M. A. Emmen et al., “Targeted disruption of the Insl3 gene causes bilateral cryptorchidism,” Molecular Endocrinology, vol. 13, no. 5, pp. 681–691, 1999. View at Google Scholar · View at Scopus
  45. P. A. Overbeek, I. P. Gorlov, R. W. Sutherland et al., “A transgenic insertion causing cryptorchidism in mice,” Genesis, vol. 30, pp. 26–35, 2001. View at Google Scholar
  46. A. Ferlin, N. V. Bogatcheva, L. Gianesello et al., “Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization,” Molecular Human Reproduction, vol. 12, no. 6, pp. 401–406, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Roh, H. Virtanen, J. Kumagai et al., “Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism,” Reproductive BioMedicine Online, vol. 7, no. 4, pp. 400–406, 2003. View at Google Scholar · View at Scopus
  48. D. Cortes, “Cryptorchidism—aspects of pathogenesis, histology and treatment,” Scandinavian Journal of Urology and Nephrology. Supplementum, vol. 196, pp. 1–54, 1998. View at Google Scholar
  49. D. S. Engeler, P. O. Hösli, H. John et al., “Early orchiopexy: prepubertal intratubular germ cell neoplasia and fertility outcome,” Urology, vol. 56, no. 1, pp. 144–148, 2000. View at Publisher · View at Google Scholar · View at Scopus
  50. P. A. Lee, L. A. O'Leary, N. J. Songer, M. T. Coughlin, M. F. Bellinger, and R. E. LaPorte, “Paternity after unilateral cryptorchidism: a controlled study,” Pediatrics, vol. 98, no. 4, pp. 676–679, 1996. View at Google Scholar · View at Scopus
  51. J. Thorup, R. McLachlan, D. Cortes et al., “What is new in cryptorchidism and hypospadias—a critical review on the testicular dysgenesis hypothesis,” Journal of Pediatric Surgery, vol. 45, no. 10, pp. 2074–2086, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. P. A. Lee and M. T. Coughlin, “Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data,” Hormone Research, vol. 55, no. 1, pp. 28–32, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. E. Matuszczak, A. Hermanowicz, W. Debek, M. Oksiuta, E. Dzienis-Koronkiewicz, and B. Zelazowska-Rutkowska, “Serum AMH concentration as a marker evaluating gonadal function in boys operated on for unilateral cryptorchidism between 1st and 4th year of life,” Endocrine, vol. 41, pp. 334–337, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Demircan, A. Akinci, and M. Mutus, “The effects of orchiopexy on serum anti-Müllerian hormone levels in unilateral cryptorchid infants,” Pediatric Surgery International, vol. 22, no. 3, pp. 271–273, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Guibourdenche, N. Lucidarme, D. Chevenne et al., “Anti-Müllerian hormone levels in serum from human foetuses and children: pattern and clinical interest,” Molecular and Cellular Endocrinology, vol. 211, no. 1-2, pp. 55–63, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. M. D. Komarowska, A. Hermanowicz, E. Matuszczak et al., “Anti-Müllerian hormone levels in serum 1 year after unilateral orchiopexy,” Journal of Pediatric Endocrinology & Metabolism, vol. 25, no. 11-12, pp. 1073–1076, 2012. View at Google Scholar
  57. L. Aksglaede, P. Christiansen, K. Sørensen et al., “Serum concentrations of anti-Müllerian hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism,” Acta Paediatrica, vol. 100, no. 6, pp. 839–845, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. R. V. Trigo, I. Bergada, R. Rey et al., “Altered serum profile of inhibin B, pro-alphaC and anti-Müllerian hormone in prepubertal and pubertal boys with varicocele,” Clinical Endocrinology, vol. 60, pp. 758–764, 2004. View at Google Scholar
  59. D. C. Goulis, G. Mintziori, N. Koliakos et al., “Inhibin B and anti-Müllerian hormone in spermatic vein of subfertile men with varicocele,” Reproductive Sciences, vol. 18, no. 6, pp. 551–555, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. S. F. Ahmed, L. Keir, J. McNeilly, P. Galloway, S. O'Toole, and A. M. Wallace, “The concordance between serum anti-Mullerian hormone and testosterone concentrations depends on duration of hCG stimulation in boys undergoing investigation of gonadal function,” Clinical Endocrinology, vol. 72, no. 6, pp. 814–819, 2010. View at Publisher · View at Google Scholar · View at Scopus
  61. R. P. Grinspon and R. A. Rey, “Anti-Müllerian hormone and sertoli cell function in paediatric male hypogonadism,” Hormone Research in Paediatrics, vol. 73, no. 2, pp. 81–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. R. H. Lustig, F. A. Conte, B. A. Kogan, and M. M. Grumbach, “Ontogeny of gonadotropin secretion in congenital anorchism: sexual dimorphism versus syndrome of gonadal dysgenesis and diagnostic considerations,” Journal of Urology, vol. 138, no. 3, pp. 587–591, 1987. View at Google Scholar · View at Scopus
  63. D. Cortes, “Cryptorchidism—aspects of pathogenesis, histology and treatment,” Scandinavian Journal of Urology and Nephrology. Supplementum, vol. 196, pp. 1–54, 1998. View at Google Scholar
  64. F. Hadziselimovic and B. Hoecht, “Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism,” Klinische Pädiatrie, vol. 220, no. 5, pp. 302–307, 2008. View at Publisher · View at Google Scholar · View at Scopus