Investigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas

Table 2

Baseline characteristics of 41 patients with GH-producing pituitary adenomas according to their tumor sizes.

Responsiveness to TRH	Macroadenomas			Microadenomas			𝑃^¶
	Responders	Non-responders	Total	Responders	Non-responders	Total
Number of patients	25	7	32	7	2	9
Tumor volume, mm^3	6937±16399	3506±3507	6187±14583	147±138	275±308	175±171	<0.026*
Age at diagnosis	43±12	38±8	42±12	33±9	47±14	36±11	0.181
BMI, kg/ m^2	25.7±2.9	28.9±3.5	26.8±3.4^a	27.7±4.1^b	N/A	27.8±4.1^b	0.674
Basal GH, 𝜇g/ L	23.6±29.7	79.1±71.4	35.8±47.0	10.6±13.9	13.0±8.3	11.2±12.5	0.012*
Basal IGF-I, 𝜇g/ L	919±309	1199±551	976±376^c	750±330	827±78	770±283^d	0.111
§Peak GH during TST, 𝜇g/ L	129.0±139.8	105.0±84.4	124.1±129.0	28.2±39.4	24.8±12.9	27.5±34.5	0.002*
^§∗ΔGHmax−min during TST, 𝜇g/ L	105.8±138.1	34.8±30.1	90.3±125.8	13.4±25.2	10.3±6.5	12.7±22.0	0.026*

Data were expressed as mean ± standard deviation.
^¶𝑃 values between macroadenomas (𝑛=32) and microadenomas (𝑛=9) were calculated using the Mann-Whitney test.
* 𝑃<0.05.
§The Mann-Whitney test only between TRH responders and non-responders with macroadenomas demonstrated the significant difference between the two groups.
^aData were available in 22 cases.
^bData were available in 4 cases.
^cData were available in 30 cases.
^dData were available in 8 cases.