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International Journal of Endocrinology
Volume 2013, Article ID 164939, 6 pages
Clinical Study

Vitamin D Status in Patients Operated for Primary Hyperparathyroidism: Comparison of Patients from Southern and Northern Europe

1Department of Surgery, Lund University Hospital, 221 85 Lund, Sweden
2Departement of Clinical Sciences, Lund University, Sweden
3Department of Surgery, Skane University Hospital, Lund University, S-221 85 Lund, Sweden
4Endocrine Surgery Unit, Department of Surgery, Barcelona, Spain

Received 2 May 2013; Revised 4 July 2013; Accepted 8 July 2013

Academic Editor: Ibrahim Sahin

Copyright © 2013 Erik Nordenström et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain and Sweden that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, ), urinary calcium (7.3 versus 4.1 mmol/L, ), and heavier adenomas (620 versus 500 g, ). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery. Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.