Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

Table 3

Subgroup analyses results of the association between GH treatment and BMD of spine

Subgroups	Effects of GH treatment on BMD			Heterogeneity
	SMD	95% CI	P	𝐼^2 (%)	𝜒^2	P
Treatment time
≤2 yr	0.311	0.159–0.463	0.000	0.0	9.62	0.565
>2 yr	0.597	0.275–0.919	0.000	73.6	22.69	0.001
GH dosage
Fixed dosage	0.429	0.172–0.686	0.001	34.2	12.16	0.144
Dosage depending on serum IGF-1 values	0.429	0.203–0.655	0.000	62.2	23.79	0.005
Manufacturer of DXA scanner
Hologic Inc	0.362	0.204–0.520	0.000	0.0	9.15	0.518
GE-lunar	0.440	0.097–0.783	0.012	74.7	23.72	0.001
Geographic location^a
Europe	0.385	0.232–0.537	0.000	13.9	12.78	0.308
America	0.461	−0.049–0.971	0.076	76.3	21.07	0.001

aThere was only one study including Oceanian subjects.