Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

Table 5

Subgroup analyses results of the association between GH treatment and BMD of TB.

Subgroups	Effects of GH treatment on BMD			Heterogeneity
	SMD	95% CI	P	𝐼^2 (%)	𝜒^2	P
Treatment time
≤2 yr	0.159	−0.148–0.466	0.311	68.1	18.81	0.004
>2 yr	0.352	0.015–0.688	0.041	70.9	13.76	0.008
GH usage
Fixed dosage	0.205	−0.406–0.816	0.512	82.7	17.35	0.001
Dosage depending on serum IGF-1 values	0.283	0.076–0.491	0.007	52.0	14.59	0.042
Manufacturer of DXA scanner
Hologic Inc	0.317	−0.101–0.736	0.137	66.8	12.06	0.017
GE-lunar	0.207	−0.083–0.497	0.162	74.8	23.77	0.001
Geographic location
Europe	0.224	−0.015–0.463	0.066	51.2	14.34	0.045
America	0.618	−0.200–1.435	0.139	78.9	4.75	0.029
Oceania	−0.028	−0.438–0.381	0.892	75.6	4.10	0.043