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International Journal of Endocrinology
Volume 2013 (2013), Article ID 313528, 7 pages
http://dx.doi.org/10.1155/2013/313528
Research Article

The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model

1Department of Nephrology, Bulent Ecevit University Medical School, Esenkoy, 67100 Zonguldak, Turkey
2Department of Internal Medicine, Ege University Medical School, 35100 Izmir, Turkey
3Department of Pharmacology, Ege University Medical School, 35100 Izmir, Turkey
4Department of Biochemistry, Ege University Medical School, 35100 Izmir, Turkey
5Department of Pathology, Ege University Medical School, 35100 Izmir, Turkey

Received 5 April 2013; Revised 28 May 2013; Accepted 30 May 2013

Academic Editor: Hulya Taskapan

Copyright © 2013 Ender Hur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. H. Whiting and P. A. J. Brown, “The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity,” Renal Failure, vol. 18, no. 6, pp. 899–909, 1996. View at Google Scholar · View at Scopus
  2. M. P. Mingeot-Leclercq and P. M. Tulkens, “Aminoglycosides: nephrotoxicity,” Antimicrobial Agents and Chemotherapy, vol. 43, no. 5, pp. 1003–1012, 1999. View at Google Scholar · View at Scopus
  3. A. A. Elfarra, R. J. Duescher, P. J. Sausen, T. M. O'Hara, and A. J. Cooley, “Methimazole protection of rats against gentamicin-induced nephrotoxicity,” Canadian Journal of Physiology and Pharmacology, vol. 72, no. 10, pp. 1238–1244, 1994. View at Google Scholar · View at Scopus
  4. T. J. Geleilete, G. C. Melo, R. S. Costa, R. A. Volpini, T. J. Soares, and T. M. Coimbra, “Role of myofibroblasts, macrophages, transforming growth factor-β endothelin, angiotensin-II, and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin,” Journal of Nephrology, vol. 15, no. 6, pp. 633–642, 2002. View at Google Scholar · View at Scopus
  5. I. T. Abdel-Raheem, A. A. Abdel-Ghany, and G. A. Mohamed, “Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats,” Biological and Pharmaceutical Bulletin, vol. 32, no. 1, pp. 61–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. B. H. Ali, “Gentamicin nephrotoxicity in humans and animals: some recent research,” General Pharmacology, vol. 26, no. 7, pp. 1477–1487, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Finkel, “Oxygen radicals and signaling,” Current Opinion in Cell Biology, vol. 10, no. 2, pp. 248–253, 1998. View at Publisher · View at Google Scholar
  8. M. El Mouedden, G. Laurent, M. Mingeot-Leclercq, H. S. Taper, J. Cumps, and P. M. Tulkens, “Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 3, pp. 665–675, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Bledsoe, S. Crickman, J. Mao et al., “Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis,” Nephrology Dialysis Transplantation, vol. 21, no. 3, pp. 624–633, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. C. J. Rosen, J. S. Adams, D. D. Bikle et al., “The nonskeletal effects of vitamin D: an endocrine society scientific statement,” vol. 33, no. 3, pp. 456–492, 2012. View at Publisher · View at Google Scholar
  11. R. Agarwal, M. Acharya, J. Tian et al., “Antiproteinuric effect of oral paricalcitol in chronic kidney disease,” Kidney International, vol. 68, no. 6, pp. 2823–2828, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Alborzi, N. A. Patel, C. Peterson et al., “Paricalcitol reduces albuminuria and inflammation in chronic kidney disease a randomized double-blind pilot trial,” Hypertension, vol. 52, no. 2, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Fishbane, H. Chittineni, M. Packman, P. Dutka, N. Ali, and N. Durie, “Oral paricalcitol in the treatment of patients with CKD and proteinuria: a randomized trial,” The American Journal of Kidney Diseases, vol. 54, no. 4, pp. 647–652, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. D. de Zeeuw, R. Agarwal, M. Amdahl et al., “Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial,” The Lancet, vol. 376, no. 9752, pp. 1543–1551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. C. Li, “Podocytes as target of vitamin D,” Current Diabetes Reviews, vol. 7, no. 1, pp. 35–40, 2011. View at Google Scholar · View at Scopus
  16. G. Laurent, M. B. Carlier, B. Rollman, F. van Hoof, and P. Tulkens, “Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin,” Biochemical Pharmacology, vol. 31, no. 23, pp. 3861–3870, 1982. View at Publisher · View at Google Scholar · View at Scopus
  17. J. S. Sandhu, A. Sehgal, O. Gupta, and A. Singh, “Aminoglycoside nephrotoxicity revisited,” Journal of Indian Academy of Clinical Medicine, vol. 8, no. 4, pp. 331–333, 2007. View at Google Scholar · View at Scopus
  18. Y. C. Li, J. Kong, M. Wei, Z. Chen, S. Q. Liu, and L. Cao, “1,25-dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system,” Journal of Clinical Investigation, vol. 110, no. 2, pp. 229–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Yuan, W. Pan, J. Kong et al., “1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter,” The Journal of Biological Chemistry, vol. 282, no. 41, pp. 29821–29830, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Zhang, L. Sun, Y. Wang et al., “Renoprotective role of the vitamin D receptor in diabetic nephropathy,” Kidney International, vol. 73, no. 2, pp. 163–171, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Zhang, J. Kong, D. K. Deb, A. Chang, and Y. C. Li, “Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system,” Journal of the American Society of Nephrology, vol. 21, no. 6, pp. 966–973, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Freundlich, Y. Quiroz, Z. Zhang et al., “Suppression of renin-angiotensin gene expression in the kidney by paricalcitol,” Kidney International, vol. 74, no. 11, pp. 1394–1402, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. X. X. Wang, T. Jiang, Y. Shen et al., “Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism,” The American Journal of Physiology, vol. 300, no. 3, pp. F801–F810, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Zhang, Y. Zhang, G. Ning, D. K. Deb, J. Kong, and C. L. Yan, “Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 41, pp. 15896–15901, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. K. Deb, T. Sun, K. E. Wong et al., “Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes,” Kidney International, vol. 77, no. 11, pp. 1000–1009, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Zhang, D. K. Deb, J. Kong et al., “Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist,” The American Journal of Physiology, vol. 297, no. 3, pp. F791–F801, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Ohara, M. Tanimoto, T. Gohda et al., “Effect of combination therapy with angiotensin receptor blocker and 1,25-dihydroxyvitamin D3 in type 2 diabetic nephropathy in KK-Ay/Ta mice,” Nephron—Experimental Nephrology, vol. 117, no. 4, pp. e124–e132, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. C. Li, “Renoprotective effects of vitamin D analogs,” Kidney International, vol. 78, no. 2, pp. 134–139, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Alborzi, N. A. Patel, C. Peterson et al., “Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial,” Hypertension, vol. 52, no. 2, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. D. de Zeeuw, R. Agarwal, M. Amdahl et al., “Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial,” The Lancet, vol. 376, no. 9752, pp. 1543–1551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Romero, M. Pérez, M. Chávez, G. Parra, and P. Durante, “Effect of uric acid on gentamicin-induced nephrotoxicity in rats—role of matrix metalloproteinases 2 and 9,” Basic and Clinical Pharmacology and Toxicology, vol. 105, no. 6, pp. 416–424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. O. A. Al-Shabanah, A. M. Aleisa, A. A. Al-Yahya et al., “Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats,” Nephrology Dialysis Transplantation, vol. 25, no. 1, pp. 69–76, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. E. S. El Daly, “Effect of methimazole and fish oil treatment on gentamicin nephrotoxicity in rats,” Journal de Pharmacie de Belgique, vol. 52, no. 4, pp. 149–156, 1997. View at Google Scholar · View at Scopus
  34. J. Pedraza-Chaverrí, P. D. Maldonado, D. Barrera, A. Cerón, O. N. Medina-Campos, and R. Hernández-Pando, “Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats,” Molecular and Cellular Biochemistry, vol. 254, no. 1-2, pp. 125–130, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Balakumar, A. Rohilla, and A. Thangathirupathi, “Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?” Pharmacological Research, vol. 62, no. 3, pp. 179–186, 2010. View at Publisher · View at Google Scholar
  36. C. Silan, O. Uzun, N. U. Çomunoǧlu, S. Gokçen, S. Bedirhan, and M. Cengiz, “Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol,” Biological and Pharmaceutical Bulletin, vol. 30, no. 1, pp. 79–83, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. K. M. Soliman, M. Abdul-Hamid, and A. I. Othman, “Effect of carnosine on gentamicin-induced nephrotoxicity,” Medical Science Monitor, vol. 13, no. 3, pp. BR73–BR83, 2007. View at Google Scholar · View at Scopus
  38. G. Laurent, P. Maldague, M. B. Carlier, and P. Tulkens, “Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats,” Antimicrobial Agents and Chemotherapy, vol. 24, no. 4, pp. 586–593, 1983. View at Publisher · View at Google Scholar
  39. M. El Mouedden, G. Laurent, M. Mingeot-Leclercq, H. S. Taper, J. Cumps, and P. M. Tulkens, “Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 3, pp. 665–675, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Bledsoe, S. Crickman, J. Mao et al., “Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis,” Nephrology Dialysis Transplantation, vol. 21, no. 3, pp. 624–633, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. P. D. Walker, Y. Barri, and S. V. Shah, “Oxidant mechanisms in gentamicin nephrotoxicity,” Renal Failure, vol. 21, no. 3-4, pp. 433–442, 1999. View at Google Scholar · View at Scopus
  42. P. D. Maldonado, D. Barrera, I. Rivero et al., “Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage,” Free Radical Biology and Medicine, vol. 35, no. 3, pp. 317–324, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. Z. Wang, L. Liu, Q. Mei, L. Liu, Y. Ran, and R. Zhang, “Increased expression of heat shock protein 72 protects renal proximal tubular cells from gentamicin-induced injury,” Journal of Korean Medical Science, vol. 21, no. 5, pp. 904–910, 2006. View at Google Scholar · View at Scopus
  44. P. Balakumar, V. A. Chakkarwar, V. Kumar, A. Jain, J. Reddy, and M. Singh, “Experimental models for nephropathy,” Journal of the Renin-Angiotensin-Aldosterone System, vol. 9, no. 4, pp. 189–195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. B. H. Ali, “The effect of treatment with the medicinal plant Rhazya stricta decne on gentamicin nephrotoxicity in rats,” Phytomedicine, vol. 9, no. 5, pp. 385–389, 2002. View at Google Scholar · View at Scopus
  46. S. Cuzzocrea, E. Mazzon, L. Dugo et al., “A role for superoxide in gentamicin-mediated nephropathy in rats,” European Journal of Pharmacology, vol. 450, no. 1, pp. 67–76, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. G. Sener, A. O. Sehirli, H. Z. Altunbas et al., “Melatonin protects against gentamicin-induced nephrotoxicity in rats,” Journal of Pineal Research, vol. 32, no. 4, pp. 231–236, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. H. Parlakpinar, S. Tasdemir, A. Polat et al., “Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats,” Toxicology, vol. 207, no. 2, pp. 169–177, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. J. Pedraza-Chaverrí, P. D. Maldonado, O. N. Medina-Campos et al., “Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes,” Free Radical Biology and Medicine, vol. 29, no. 7, pp. 602–611, 2000. View at Publisher · View at Google Scholar · View at Scopus
  50. P. D. Maldonado, D. Barrera, O. N. Medina-Campos, R. Hernández-Pando, M. E. Ibarra-Rubio, and J. Pedraza-Chaverrí, “Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats,” Life Sciences, vol. 73, no. 20, pp. 2543–2556, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. A. B. Abdel-Naim, M. H. Abdel-Wahab, and F. F. Attia, “Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rats,” Pharmacological Research, vol. 40, no. 2, pp. 183–187, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Shirwaikar, S. Malini, and S. C. Kumari, “Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats,” Indian Journal of Experimental Biology, vol. 41, no. 1, pp. 58–62, 2003. View at Google Scholar · View at Scopus
  53. A. Ateşşahin, I. Karahan, S. Yilmaz, A. O. Çeribaşi, and I. Princci, “The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats,” Pharmacological Research, vol. 48, no. 6, pp. 637–642, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Polat, H. Parlakpinar, S. Tasdemir et al., “Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats,” Acta Histochemica, vol. 108, no. 5, pp. 365–371, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Ozbek, M. Cekmen, Y. O. Ilbey, A. Simsek, E. C. Polat, and A. Somay, “Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-κB pathways,” Renal Failure, vol. 31, no. 5, pp. 382–392, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. I. T. Abdel-Raheem, G. A. El-Sherbiny, and A. Taye, “Green tea ameliorates renal oxidative damage induced by gentamicin in rats,” Pakistan Journal of Pharmaceutical Sciences, vol. 23, no. 1, pp. 21–28, 2010. View at Google Scholar · View at Scopus
  57. B. V. S. Lakshmi and M. Sudhakar, “Protective effect of Zingiber officinale on gentamicin-induced nephrotoxicity in rats,” International Journal of Pharmacology, vol. 6, no. 1, pp. 58–62, 2010. View at Publisher · View at Google Scholar · View at Scopus
  58. S. M. Wahl, D. A. Hunt, and L. M. Wakefield, “Transforming growth factor type β induces monocyte chemotaxis and growth factor production,” Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 16, pp. 5788–5792, 1987. View at Google Scholar · View at Scopus
  59. W. W. Tang, L. Feng, J. C. Mathison, and C. B. Wilson, “Cytokine expression, upregulation of intercellular adhesion molecule-1, and leukocyte infiltration in experimental tubulointerstitial nephritis,” Laboratory Investigation, vol. 70, no. 5, pp. 631–638, 1994. View at Google Scholar · View at Scopus
  60. I. Yildirim, K. Magden, and E. Hur, “Infection inflammation and vitamin D,” Clinical Microbiology, vol. 2, article 116, 2013. View at Publisher · View at Google Scholar