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International Journal of Endocrinology
Volume 2013 (2013), Article ID 316783, 6 pages
http://dx.doi.org/10.1155/2013/316783
Review Article

Silicon: A Review of Its Potential Role in the Prevention and Treatment of Postmenopausal Osteoporosis

Orlando Health Department of Orthopedic Surgery, 1222 Orange Avenue, Orlando, FL 32806, USA

Received 23 December 2012; Accepted 23 April 2013

Academic Editor: Cory Xian

Copyright © 2013 Charles T. Price et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. United States Department of Health and Human Services, Bone Health and Osteoporosis: A Report of the Surgeon General, Department of Health and Human Services, Office of the Surgeon General, Rockville, Md, USA, 2004.
  2. J.-J. Body, P. Bergmann, S. Boonen et al., “Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club,” Osteoporosis International, vol. 22, no. 11, pp. 2769–2788, 2011. View at Google Scholar
  3. A. Carmel, A. Shieh, H. Bang, and R. S. Bockman, “The 25(OH)D level needed to maintain a favorable bisphosphonate response is 33 ng/ml,” Osteoporosis International, vol. 23, no. 10, pp. 2479–2487, 2012. View at Google Scholar
  4. H. A. Bischoff-Ferrari, B. Dawson-Hughes, J. A. Baron et al., “Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials,” American Journal of Clinical Nutrition, vol. 86, no. 6, pp. 1780–1790, 2007. View at Google Scholar · View at Scopus
  5. H. A. Bischoff-Ferrari, W. C. Willett, E. J. Orav et al., “A pooled analysis of vitamin D dose requirements for fracture prevention,” The New England Journal of Medicine, vol. 367, no. 1, pp. 40–49, 2012. View at Google Scholar
  6. J. W. Nieves, “Skeletal effects of nutrients and neutraceuticals, beyond calcium and vitamin D,” Osteoporosis Inernational, vol. 24, no. 3, pp. 771–786, 2013. View at Google Scholar
  7. S. Levis and V. S. Lagari, “The role of diet in osteoporosis prevention and management,” Current Osteoporosis Reports, vol. 10, no. 4, pp. 296–302, 2012. View at Google Scholar
  8. T. Ushiroyama, A. Ikeda, and M. Ueki, “Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women,” Maturitas, vol. 41, no. 3, pp. 211–221, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. A. A. Poundarik, T. Diab, G. E. Sroga et al., “Dilational band formation in bone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 47, pp. 19178–19183, 2012. View at Publisher · View at Google Scholar
  10. R. B. Ervin, C. Y. Wang, J. D. Wright, and J. Kennedy-Stephens, Dietary Intake of Selected Minerals for the United States Population: 1999-2000, Advance Data from Vital Health Statistics, no. 341, National Center for Health Statistics, Hyattsville, Md, USA, 2004.
  11. R. B. Ervin, J. D. Wright, C. Y. Wang, and J. Kennedy-Stephens, Dietary Intake of Selected Vitamins for the United States Population: 1999-2000, Advance Data from Vital Health Statistics, no. 339, National Center for Health Statistics, Hyattsville, Md, USA, 2004.
  12. C. T. Price, J. R. Langford, and F. A. Liporace, “Essential nutrients for bone health and a review of their availability in the average North American diet,” Open Orthopaedics Journal, vol. 6, pp. 143–149, 2012. View at Google Scholar
  13. W. M. C. Chumlea, “Silica, a mineral of unknown but emerging health importance,” Journal of Nutrition, Health and Aging, vol. 11, no. 2, p. 93, 2007. View at Google Scholar · View at Scopus
  14. R. Jugdaohsingh, “Silicon and bone health,” Journal of Nutrition, Health and Aging, vol. 11, no. 2, pp. 99–110, 2007. View at Google Scholar · View at Scopus
  15. E. M. Carlisle, “Silicon: a requirement in bone formation independent of vitamin D1,” Calcified Tissue International, vol. 33, no. 1, pp. 27–34, 1981. View at Google Scholar · View at Scopus
  16. F. H. Nielsen and H. H. Sandstead, “Are nickel, vanadium, silicon, fluorine, and tin essential for man? A review,” American Journal of Clinical Nutrition, vol. 27, no. 5, pp. 515–520, 1974. View at Google Scholar · View at Scopus
  17. E. M. Carlisle, “Silicon: a possible factor in bone calcification,” Science, vol. 167, no. 3916, pp. 279–280, 1970. View at Google Scholar · View at Scopus
  18. E. M. Carlisle, “A relationship between silicon and calcium in bone formation,” Federal Proceedings, vol. 29, p. 565, 1970. View at Google Scholar
  19. K. Schwarz and D. B. Milne, “Growth-promoting effects of silicon in rats,” Nature, vol. 239, no. 5371, pp. 333–334, 1972. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hott, C. de Pollak, D. Modrowski, and P. J. Marie, “Short-term effects of organic silicon on trabecular bone in mature ovariectomized rats,” Calcified Tissue International, vol. 53, no. 3, pp. 174–179, 1993. View at Google Scholar · View at Scopus
  21. H. M. Macdonald, A. C. Hardcastle, R. Jugdaosingh, W. D. Fraser, D. M. Reid, and J. J. Powell, “Dietary silicon interacts with oestrogen to influence bone health: evidence from the Aberdeen Prospective Osteoporosis Screening Study,” Bone, vol. 50, no. 3, pp. 681–687, 2012. View at Google Scholar
  22. K. R. Martin, “The chemistry of silica and its potential health benefits,” Journal of Nutrition, Health and Aging, vol. 11, no. 2, pp. 94–98, 2007. View at Google Scholar · View at Scopus
  23. W. Peters, D. Smith, and S. Lugowski, “Silicon assays in women with and without silicone gel breast implants—a review,” Annals of Plastic Surgery, vol. 43, no. 3, pp. 324–330, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Sripanyakorn, R. Jugdaohsingh, W. Dissayabutr, S. H. C. Anderson, R. P. H. Thompson, and J. J. Powell, “The comparative absorption of silicon from different foods and food supplements,” British Journal of Nutrition, vol. 102, no. 6, pp. 825–834, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Giammarioli, M. Mosca, and E. Sanzini, “Silicon content of Italian mineral waters and its contribution to daily intake,” Journal of Food Science, vol. 70, no. 8, pp. S509–S512, 2005. View at Google Scholar · View at Scopus
  26. F. Aguilar, B. Dusemund, P. Galtier et al., “Scientific opinion: monomethylsilanetriol added for nutritional purposes to food supplements,” European Food Safety Authority Journal, vol. 950, pp. 1–12, 2009. View at Google Scholar
  27. H. J. Gitelman, F. R. Alderman, and S. J. Perry, “Silicon accumulation in dialysis patients,” American Journal of Kidney Diseases, vol. 19, no. 2, pp. 140–143, 1992. View at Google Scholar · View at Scopus
  28. Y. Fujino, Y. Inoue, M. Onodera et al., “Case of concrete hardener poisoning complicated with acute renal failure treated by hemodialysis,” Chudoku Kenkyu, vol. 20, no. 3, pp. 263–268, 2007 (Japanese). View at Google Scholar · View at Scopus
  29. M. H. Lee, Y. H. Lee, T. H. Hsu, M. T. Chen, and L. S. Chang, “Silica stone—development due to long time oral trisilicate intake. Case report,” Scandinavian Journal of Urology and Nephrology, vol. 27, no. 2, pp. 267–269, 1993. View at Google Scholar · View at Scopus
  30. E. M. Carlisle, “In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick,” Journal of Nutrition, vol. 106, no. 4, pp. 478–484, 1976. View at Google Scholar · View at Scopus
  31. K. Schwarz, “A bound form of silicon in glycosaminoglycans and polyuronides,” Proceedings of the National Academy of Sciences of the United States of America, vol. 70, no. 5, pp. 1608–1612, 1973. View at Google Scholar · View at Scopus
  32. D. M. Reffitt, N. Ogston, R. Jugdaohsingh et al., “Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro,” Bone, vol. 32, no. 2, pp. 127–135, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. C. D. Seaborn and F. H. Nielsen, “Dietary silicon and arginine affect mineral element composition of rat femur and vertebra,” Biological Trace Element Research, vol. 89, no. 3, pp. 239–250, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. C. D. Seaborn and F. H. Nielsen, “Dietary silicon affects acid and alkaline phosphatase and 45calcium uptake in bone of rats,” Journal of Trace Elements in Experimental Medicine, vol. 7, no. 1, pp. 11–18, 1994. View at Google Scholar · View at Scopus
  35. Y. Kanda, “Piezpresistance effect of silicon,” Sensors and Actuators A, vol. 28, no. 2, pp. 83–91, 1991. View at Google Scholar
  36. T. Miclau, K. J. Bozic, B. Tay et al., “Bone injury, regeneration, and repair,” in Orthopedic Basic Science: Foundations of ClInical Practice, T. A. Einhorn, R. J. O'Keefe, and J. A. Buckwalter, Eds., pp. 331–348, American Adacemy of Orthopedic Surgeons, Rosemont, Ill, USA, 2007. View at Google Scholar
  37. K. Sahin, M. Onderci, N. Sahin et al., “Dietary arginine silicate inositol complex improves bone mineralization in quail,” Poultry Science, vol. 85, no. 3, pp. 486–492, 2006. View at Google Scholar · View at Scopus
  38. F. Z. Küçükbay, H. Yazlak, N. Sahin et al., “Effects of dietary arginine silicate inositol complex on mineral status in rainbow trout (Oncorhynchus mykiss),” Aquaculture Nutrition, vol. 14, no. 3, pp. 257–262, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. J. W. Merkley and E. R. Miller, “The effect of sodium fluoride and sodium silicate on growth and bone strength of broilers,” Poultry Science, vol. 62, no. 5, pp. 798–804, 1983. View at Google Scholar · View at Scopus
  40. B. D. Nielsen, G. D. Potter, E. L. Morris et al., “Training distance to failure in young racing quarter horses fed sodium zeolite A,” Journal of Equine Veterinary Science, vol. 13, no. 10, pp. 562–567, 1993. View at Google Scholar
  41. H. Rico, J. L. Gallego-Lago, E. R. Hernandez et al., “Effect of silicon supplement on osteopenia induced by ovariectomy in rats,” Calcified Tissue International, vol. 66, no. 1, pp. 53–55, 2000. View at Google Scholar · View at Scopus
  42. Y. J. Bae, J. Y. Kim, M. K. Choi, Y. S. Chung, and M. H. Kim, “Short-term administration of water-soluble silicon improves mineral density of the femur and tibia in ovariectomized rats,” Biological Trace Element Research, vol. 124, no. 2, pp. 157–163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. M. H. Kim, Y. J. Bae, M. K. Choi, and Y. S. Chung, “Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption,” Biological Trace Element Research, vol. 128, no. 3, pp. 239–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. D. N. Kalu, “The ovariectomized rat model of postmenopausal bone loss,” Bone and Mineral, vol. 15, no. 3, pp. 175–191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Calomme, P. Geusens, N. Demeester et al., “Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid,” Calcified Tissue International, vol. 78, no. 4, pp. 227–232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. T. D. Spector, M. R. Calomme, S. H. Anderson et al., “Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial,” BMC Musculoskeletal Disorders, vol. 9, article 85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. H. Kayongo-Male and J. L. Julson, “Effects of high levels of dietary silicon on bone development of growing rats and turkeys fed semi-purified diets,” Biological Trace Element Research, vol. 123, no. 1–3, pp. 191–201, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. M. J. Coathup, S. Samizadeh, Y. S. Fang, T. Buckland, K. A. Hing, and G. W. Blunn, “The osteoinductivity of silicate-substututed calcium phosphate,” Journal of Bone and Joint Surgery. American, vol. 93, no. 23, pp. 2219–2226, 2011. View at Google Scholar
  49. A. M. Pietak, J. W. Reid, M. J. Stott, and M. Sayer, “Silicon substitution in the calcium phosphate bioceramics,” Biomaterials, vol. 28, no. 28, pp. 4023–4032, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. W. Waked and J. Grauer, “Silicates and bone fusion,” Orthopedics, vol. 31, no. 6, pp. 591–597, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Bohner, “Silicon-substituted calcium phosphates—a critical view,” Biomaterials, vol. 30, no. 32, pp. 6403–6406, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. F. Chen, P. Cole, L. Wen, Z. Mi, and E. J. Trapido, “Estimates of trace element intakes in Chinese farmers,” Journal of Nutrition, vol. 124, no. 2, pp. 196–201, 1994. View at Google Scholar · View at Scopus
  53. A. Anasuya, S. Bapurao, and P. K. Paranjape, “Fluoride and silicon intake in normal and endemic fluorotic areas,” Journal of Trace Elements in Medicine and Biology, vol. 10, no. 3, pp. 149–155, 1996. View at Google Scholar · View at Scopus
  54. O. Johnell and J. A. Kanis, “An estimate of the worldwide prevalence, mortality and disability associated with hip fracture,” Osteoporosis International, vol. 15, no. 11, pp. 897–902, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. R. Jugdaohsingh, K. L. Tucker, N. Qiao, L. A. Cupples, D. P. Kiel, and J. J. Powell, “Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort,” Journal of Bone and Mineral Research, vol. 19, no. 2, pp. 297–307, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. S. A. McNaughton, C. Bolton-Smith, G. D. Mishra, R. Jugdaohsingh, and J. J. Powell, “Dietary silicon intake in post-menopausal women,” British Journal of Nutrition, vol. 94, no. 5, pp. 813–817, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. H. J. Bowen and A. Peggs, “Determination of the silicon content of food,” Journal of the Science of Food and Agriculture, vol. 35, no. 11, pp. 1225–1229, 1984. View at Google Scholar
  58. R. Jugdaohsingh, S. H. C. Anderson, K. L. Tucker et al., “Dietary silicon intake and absorption,” American Journal of Clinical Nutrition, vol. 75, no. 5, pp. 887–893, 2002. View at Google Scholar · View at Scopus
  59. H. M. Macdonald, A. E. Hardcastle, R. Jugdaohsingh, and D. M. Reid, “Dietary silicon intake is associated with bone mineral density in premenopausal women and postmenopausal women taking HRT,” Journal of Bone and Mineral Research, vol. 20, p. S393, 2005. View at Google Scholar
  60. M. Ten Bolscher, J. C. Netelenbos, R. Barto, L. M. van Buuren, and W. J. F. van der Vijgh, “Estrogen regulation of intestinal calcium absorption in the intact and ovariectomized adult rat,” Journal of Bone and Mineral Research, vol. 14, no. 7, pp. 1197–1202, 1999. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Eisinger and D. Clairet, “Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study,” Magnesium Research, vol. 6, no. 3, pp. 247–249, 1993. View at Google Scholar · View at Scopus
  62. A. Schiano, F. Eisinger, P. Detolle, A. M. Laponche, B. Brisou, and J. Eisinger, “Silicium, bone tissue and immunity,” Revue du Rhumatisme et des Maladies Ostéo-Articulaires, vol. 46, no. 7–9, pp. 483–486, 1979. View at Google Scholar · View at Scopus
  63. Z. Li, H. Karp, A. Zerlin, T. Y. A. Lee, C. Carpenter, and D. Heber, “Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study,” Nutrition Journal, vol. 9, no. 1, article 44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. J. J. Powell, S. A. McNaughton, R. Jugdaohsingh et al., “A provisional database for the silicon content of foods in the United Kingdom,” British Journal of Nutrition, vol. 94, no. 5, pp. 804–812, 2005. View at Publisher · View at Google Scholar · View at Scopus
  65. K. L. Tucker, R. Jugdaohsingh, J. J. Powell et al., “Effects of beer, wine, and liquor intakes on bone mineral density in older men and women,” American Journal of Clinical Nutrition, vol. 89, no. 4, pp. 1188–1196, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. S. Sripanyakorn, R. Jugdaohsingh, A. Mander, S. L. Davidson, R. P. H. Thompson, and J. J. Powell, “Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTX in a PTH-independent fashion,” Journal of Bone and Mineral Research, vol. 24, no. 8, pp. 1380–1388, 2009. View at Publisher · View at Google Scholar · View at Scopus