Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide

Table 4

Multivariate predictors of ΔHbA1c after sulfonylurea treatment.

Independent variables	Model 1	Model 2
	𝑃	𝑃
TCF7L2 genotype	0.006	0.002
Sulfonylurea type	0.419	0.028
TCF7L2 genotype * sulfonylurea type	—	0.023
HbA1c baseline	<0.001	<0.001
Age	0.801	0.713
Gender	0.385	0.335
BMI	0.246	0.240
Sulfonylurea dose	0.218	0.380

Coding of the variables: TCF7L2 genotype: CC-0, CT + TT-1; sulfonylurea type: gliclazide-1, other sulfonylureas-2; gender: male-1, female-2.