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International Journal of Endocrinology
Volume 2013, Article ID 394934, 9 pages
Clinical Study

Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation

Department of Experimental Medicine, Section of Medical Pathophysiology, viale Regina Elena 324, Sapienza University of Rome, 00161 Rome, Italy

Received 29 January 2013; Accepted 20 February 2013

Academic Editor: Felice Strollo

Copyright © 2013 Davide Francomano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men with LL-PE (18–40 years) were enrolled in an 8-week, double-blind, placebo-controlled, crossover study and compared with 10 age-matched controls without LL-PE. Primary endpoints were PAT modifications induced by vardenafil 10 mg on demand. Secondary endpoints were the improvement in intravaginal ejaculatory latency time (IELT) as measured by the stopwatch technique and variations in anxiety scores at Stai-X1 for state-anxiety and Stai-X2 for trait-anxiety. At baseline, men with LL-PE showed higher RHI variation ( ), Stai-X1 and Stai X2 scores ( , resp.), and prolactin levels ( ) compared with controls. Vardenafil treatment markedly reduced RHI variation in men with LL-PE ( ) when compared with placebo. Mean changes in geometric IELT were higher after taking vardenafil (0.6 ± 0.3 versus 4.5 ± 1.1 min, ) when compared with placebo. STAI-X1 and STAI-X2 scores fell within the normal range after treatment with vardenafil ( ). Vardenafil was an effective treatment in men with LL-PE; improvements of IELT may be due to increased NO production which is able to reduce adrenergic overactivity and anxiety levels.