Review Article
Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Table 3
Increase in PVAT amount and adipocyte size in different models of obesity.
| Species | Model | PVAT | Adipocyte size | Study reference |
| Wistar rat | HFD (6 mo) | Aortic | Increase | [19] | Wistar Kyoto rat | HFD (3 mo—60% cal from fat) | Aortic | Increase | [63] | Zucker fa/fa rat | | Aortic | Increase | [63] | C57Bl6 mice | HFD (2 w—42% cal from fat) | Aortic | Increase | [56] | C57Bl6 mice | HFD (13–20 w—45% cal from fat) | Thoracic aortic | No change | [58] | C57Bl6 mice | HFD (8 w—45% cal from fat) | Mesenteric | Increase | [17] | C57Bl6 mice | HFD (32 w—45% cal from fat) | Mesenteric | Increase | [28] |
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HFD: high fat diet; mo: month; w: weeks.
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