International Journal of Endocrinology / 2013 / Article / Fig 1

Review Article

The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

Figure 1

The role of adipose tissue- (AT-) gut-brain axis peptides in long-term and short-term regulation of food intake. Long-term regulators are adipose-derived food intake-inhibiting hormone leptin or food intake-stimulating hormone neuropeptide Y (NPY) mainly produced by the hypothalamus and also cosecreted with synthesized catecholamines in AT. Hormones produced in the gut are short-term food intake-stimulating hormone ghrelin, or food intake-inhibiting peptide YY (PYY), pancreatic polypeptide (PP), cholecystokinin (CCK), insulin, and putative anorexigen obestatin (the hypothalamus (violet), nucleus tractus solitarius (NTS, blue), sympathetic and serotoninergic areas (red), and vagal nerve parasympathetic area (green)).

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.