Establishing Reference Intervals for Bone Turnover Markers in the Healthy Shanghai Population and the Relationship with Bone Mineral Density in Postmenopausal Women
Table 3
Geometric means and 95% confidence intervals (95% CI) for the age-specific measurements of bone turnover markers in healthy women.
Age
Number
–CTX (ng/mL)
P1NP (ng/mL)
OC (ng/mL)
PTH (pg/mL)
20–24
145
0.412* (0.354–0.470)
54.97* (47.87–62.06)
21.23* (18.72–22.47)
37.20 (35.07–39.33)
25–29
386
0.335* (0.304–0.367)
45.94* (41.38–50.49)
18.48* (17.19–19.77)
35.70 (34.29–37.10)
30–34
247
0.280* (0.230–0.313)
40.21* (35.78–44.63)
16.80* (15.33–18.26)
36.45 (34.76–38.13)
35–39
210
0.250 (0.221–0.284)
35.93 (31.72–40.13)
15.37 (13.95–16.78)
38.10 (35.99–40.21)
40–44
178
0.239 (0.201–0.271)
34.27 (30.50–38.04)
13.84 (12.48–15.27)
38.55 (36.17–40.94)
45–49
104
0.278* (0.221–0.310)
36.35* (31.10–41.58)
14.84* (12.88–16.79)
38.99 (36.09–41.89)
50–54
138
0.470* (0.399–0.541)
52.72*(45.54–56.90)
23.46* (20.44–26.46)
35.83 (33.58–38.08)
55–59
184
0.474* (0.407–0.540)
50.21* (43.85–56.57)
24.94* (22.19–27.68)
36.50 (34.76–38.24)
60–64
51
0.441* (0.307–0.584)
47.07* (34.78–59.36)
26.40* (20.28–32.60)
37.92 (32.71–43.13)
65–69
70
0.471* (0.356–0.585)
50.61* (38.11–63.11)
25.57* (22.90–28.22)
36.13 (32.72–39.55)
70–74
77
0.431* (0.297–0.565)
50.04* (37.94–62.13)
26.50* (20.82–32.17)
35.57 (30.94–38.21)
75–79
66
0.384* (0.284–0.482)
45.44* (35.60–54.47)
24.11* (18.85–29.37)
36.25 (29.70–38.81)
Reference valuea
406
0.242 (0.218–0.297)
35.22 (30.67–40.10)
15.05 (13.81–16.59)
37.30 (33.18–40.92)
All values are presented as the geometric means (95% CI).
*
versus reference values.
aReference values were calculated from the 35–45-year-old cohort as the geometric mean (95% CI).
