Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2013 (2013), Article ID 518046, 10 pages
http://dx.doi.org/10.1155/2013/518046
Review Article

Role of GnRH Neurons and Their Neuronal Afferents as Key Integrators between Food Intake Regulatory Signals and the Control of Reproduction

Juan Roa1,2,3

1Department of Cell Biology, Physiology and Immunology, University of Córdoba, Avenida Menéndez Pidal s/n, 14004 Córdoba, Spain
2CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain
3Instituto Maimónides de Investigaciones Biomédicas (IMIBIC)/Hospital Universitario Reina Sofia, Córdoba, Spain

Received 28 June 2013; Accepted 7 August 2013

Academic Editor: Carlos Dieguez

Copyright © 2013 Juan Roa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Giulia Garaffo, Massimo Santoro, Giorgio R. Merlo, Paolo Provero, Ivan Molineris, Patrizia Pinciroli, Clelia Peano, Cristina Battaglia, Daniela Tomaiuolo, Talya Etzion, and Yoav Gothilf, “Profiling, bioinformatic, and functional data on the developing olfactory/GnRH system reveal cellular and molecular pathways essential for this process and potentially relevant for the Kallmann syndrome,” Frontiers in Endocrinology, vol. 4, 2013. View at Publisher · View at Google Scholar
  • David Garcia-Galiano, Susan J. Allen, and Carol F. Elias, “Role of the adipocyte-derived hormone leptin in reproductive control,” Hormone Molecular Biology and Clinical Investigation, vol. 19, no. 3, pp. 141–149, 2014. View at Publisher · View at Google Scholar
  • Md. Shahjahan, Takashi Kitahashi, and Ishwar S. Parhar, “Central Pathways Integrating Metabolism and Reproduction in Teleosts,” Frontiers in Endocrinology, vol. 5, 2014. View at Publisher · View at Google Scholar
  • T I Romantsova, “Reproduction and energy balance: the integrative role of prolactin,” Obesity and metabolism, vol. 11, no. 1, pp. 5–18, 2014. View at Publisher · View at Google Scholar
  • Abdoulaye Diane, Maria Kupreeva, Faye Borthwick, Spencer D. Proctor, W. David Pierce, and Donna F. Vine, “Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model,” Journal Of Endocrinology, vol. 226, no. 3, pp. 193–206, 2015. View at Publisher · View at Google Scholar
  • Alexander V. Sirotkin, Diana Kardošová, Saleh Hamad Alwasel, and Abdel Halim Harrath, “Neuropeptide Y directly affects ovarian cell proliferation and apoptosis,” Reproductive Biology, 2015. View at Publisher · View at Google Scholar
  • Giulia Garaffo, Daniele Conte, Paolo Provero, Daniela Tomaiuolo, Zheng Luo, Patrizia Pinciroli, Clelia Peano, Ilaria D'Atri, Yorick Gitton, Talya Etzion, Yoav Gothilf, Dafne Gays, Massimo M. Santoro, and Giorgio R. Merlo, “The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system,” Molecular and Cellular Neuroscience, 2015. View at Publisher · View at Google Scholar
  • Thomas T. Chen, Eugene I. Maevsky, and Mikhail L. Uchitel, “Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate,” Frontiers in Endocrinology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Lisa Yang, and Waljit Dhillo, “Kisspeptin as a therapeutic target in reproduction,” Expert Opinion on Therapeutic Targets, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • M. C. Evans, M. Z. Rizwan, and G. M. Anderson, “ Insulin Does Not Target CamkIIα Neurones to Critically Regulate the Neuroendocrine Reproductive Axis in Mice ,” Journal of Neuroendocrinology, vol. 27, no. 12, pp. 899–910, 2015. View at Publisher · View at Google Scholar
  • Maria Manfredi-Lozano, Juan Roa, Francisco Ruiz-Pino, Richard Piet, David Garcia-Galiano, Rafael Pineda, Aurora Zamora, Silvia Leon, Miguel A. Sanchez-Garrido, Antonio Romero-Ruiz, Carlos Dieguez, Maria Jesus Vazquez, Allan E. Herbison, Leonor Pinilla, and Manuel Tena-Sempere, “Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty,” Molecular Metabolism, 2016. View at Publisher · View at Google Scholar
  • Olga I. Kubrak, Oleh V. Lushchak, Meet Zandawala, and Dick R. Nässel, “ Systemic corazonin signalling modulates stress responses and metabolism in Drosophila ,” Open Biology, vol. 6, no. 11, pp. 160152, 2016. View at Publisher · View at Google Scholar
  • Chrysanthi Fergani, and Víctor M Navarro, “Expanding the role of tachykinins in the neuroendocrine control of reproduction,” Reproduction, vol. 153, no. 1, pp. R1–R14, 2016. View at Publisher · View at Google Scholar
  • Olga I. Kubrak, Oleh V. Lushchak, Meet Zandawala, and Dick R. Nässel, “Systemic corazonin signalling modulates stress responses and metabolism in Drosophila,” Open Biology, vol. 6, no. 11, 2016. View at Publisher · View at Google Scholar
  • M. Manfredi-Lozano, J. Roa, and M. Tena-Sempere, “Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility,” Frontiers in Neuroendocrinology, 2017. View at Publisher · View at Google Scholar
  • Danielle T. Porter, David A. Roberts, and Karen P. Maruska, “ Distribution and female reproductive state differences in orexigenic and anorexigenic neurons in the brain of the mouth brooding African cichlid fish, Astatotilapia burtoni ,” Journal of Comparative Neurology, 2017. View at Publisher · View at Google Scholar
  • John P. Chang, and Joshua G. Pemberton, “Comparative aspects of GnRH-Stimulated signal transduction in the vertebrate pituitary – Contributions from teleost model systems,” Molecular and Cellular Endocrinology, 2017. View at Publisher · View at Google Scholar