Calcium Activity of Upper Thoracic Dorsal Root Ganglion Neurons in Zucker Diabetic Fatty Rats

Table 3

Results from stimulation with capsaicin-containing solutions. Results are shown as Median (5th percentile; 95th percentile).

Animal	Stimulus	𝑛	Δ	%-Δ	AUC0-60s	AUCcap/AUCK^+	Δcap/ΔK^+	%-Δcap/%-ΔK^+
Control	0.3/0.5 μM Cap	32	0.22 (0.12; 0.88)	31.13 (19.85; 148.10)	2.94 (0.98; 15.09)	0.10 (0.03; 0.61)	0.23 (0.09; 0.68)	0.23 (0.09; 0.71)
	0.3/0.5 μM Cap + AC	45	0.21 (0.11; 1.34)	35.29 (20.89; 250.89)	2.88 (0.72; 48.31)	0.23 (0.01; 0.83)	0.42 (0.08; 0.99)	0.44 (0.08; 1.11)
	0.3 μM Cap + AC + pH 6.0	60	0.42 (0.12; 1.64)	73.81 (22.70; 289.41)	4.10 (0.85; 64.82)	0.09 (0.01; 4.56)	0.44 (0.12; 1.66)	0.42 (0.11; 1.74)
	0.5 μM Cap + AC + pH 6.0	13	1.7 (0.21; 2.37)	240.67 (30.89; 352.63)	72.13 (1.58; 117.24)	0.83 (0.12; 4.75)	1.35 (0.25; 2.39)	1.47 (0.25; 2.30)
Diabetic	0.3/0.5 μM Cap	55	0.41 (0.12; 1.50) *	61.54 (21.88; 218.25) ^#	4.83 (1.13; 55.17) *	0.26 (0.03; 0.89) *	0.42 (0.07; 1.12)	0.46 (0.07; 1.14) *
	0.3/0.5 μM Cap + AC	58	0.27 (0.11; 1.53)	47.62 (20.81; 294.64)	3.22 (0.90; 60.81)	0.12 (0.03; 1.32)	0.28 (0.13; 1.16)	0.29 (0.13; 1.20
	0.3 μM Cap + AC + pH 6.0	7	0.23 (0.11; 1.55)	35.09 (24.44; 249.06)	2.34 (1.33; 38.01)	0.14 (0.03; 0.56)	0.21 (0.08; 1.04)	0.23 (0.08; 1.06)
	0.5 μM Cap + AC + pH 6.0	63	1.63 (0.16; 1.87)	276.27 (22.75; 414.13)	63.51 (2.87; 97.95)	0.84 (0.02; 5.13)	1.24 (0.11; 1.93)	1.21 (0.11; 2.12)

Results are shown as AUC_0-60s, relative AUC (AUC_cap/AUC_K⁺), peak height (Δ), % increase from baseline (%-Δ), relative peak height relative to peak height of the preceding K⁺ response (Δcap/ΔK⁺ and %-Δ_cap/%-Δ_K⁺). 𝑛; number of cells, AUC; area under the curve; cap, capsaicin. ∗P < 0.05, #P < 0.01 compared to control neurons.