Figure 3: Changes in serum levels of free T and E2 throughout 24 months of treatment. Note: data are means ± SD. T: testosterone; E2: estradiol; *: versus baseline, groups B and C; ∧: versus baseline and group C. ♦: group A, the standard-dose TU group; ■: group B, the low-dose TU group; ▲: group C, placebo group.