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International Journal of Endocrinology
Volume 2013, Article ID 607939, 6 pages
Review Article

Estrogens as Antioxidant Modulators in Human Fertility

1Division of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
2Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy

Received 23 April 2013; Revised 28 October 2013; Accepted 28 October 2013

Academic Editor: Maria L. Dufau

Copyright © 2013 A. Mancini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.