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International Journal of Endocrinology
Volume 2013, Article ID 681205, 5 pages
http://dx.doi.org/10.1155/2013/681205
Research Article

Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes

1Department of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong Youngdeungpo-gu, Seoul 150-713, Republic of Korea
2Department of Internal Medicine, Hando Hospital, Seonbu 1-dong, Danwon-gu, Ansan 425-140, Republic of Korea
3Department of Surgery, The Catholic University of Korea, Seoul, Republic of Korea

Received 31 May 2013; Accepted 20 August 2013

Academic Editor: Ricardo V. García-Mayor

Copyright © 2013 Mee Kyoung Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline ( ). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery.