Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women

Table 2

Age-related serums OPG, TGF-β1, and TGF-β2 and BDR at different skeletal sites in native Chinese women.

Parameter	Age (year)
	35–44; (𝑛=128)	45–54; (𝑛=146)	55–64; (𝑛=117)	≥65; (𝑛=74)
OPG (pmol/L)^a	2.61 ± 1.88^b	4.76 ± 1.84^c	4.09 ± 1.87	3.77 ± 1.88
TGF-β1 (μg/L)^a	38.9 ± 1.64^b	25.2 ± 1.63	25.0 ± 1.52	24.9 ± 1.44
TGF-β2 (μg/L)^a	11.9 ± 1.32^b	14.2 ± 1.33	14.0 ± 1.34	13.6 ± 1.31
PA-BDR (%)	−1.72 ± 11.3^b	−13.1 ± 13.8^c	−23.6 ± 10.8	−26.3 ± 11.4
FN-BDR (%)	−3.07 ± 12.5^b	−10.2 ± 14.5^c	−21.1 ± 11.1^d	−27.4 ± 9.85
Hip-BDR (%)	−2.34 ± 12.2^b	−9.96 ± 13.7^c	−18.6 ± 10.8^d	−25.0 ± 10.1
RUUD-BDR (%)	−1.02 ± 9.62^b	−9.61 ± 13.6^c	−24.1 ± 10.9^d	−34.1 ± 10.3^e

OPG: osteoprotegerin, TGF-β: transforming growth factor-beta, BDR: bone mineral density decrease rate, PA: posteroanterior spine, FN: femoral neck, Hip: total hip, and RUUD: radius + ulna ultradistal.
^aValues are geometric mean ± SD.
^b𝑃=0.012–0.000 compared with 45–54, 55–64 and ≥65-year age groups.
^c𝑃=0.049–0.000 compared with 55–64 and ≥65-year age groups.
^d𝑃=0.011–0.000 compared with ≥65-year age group.
^e𝑃=0.003–0.000 compared with other sites in the same age group.